失眠患者血清甲状腺激素及多巴胺水平与中医证型的关系

目的 通过检测失眠患者血清甲状腺激素（TH）、多巴胺（DA）的含量，分析TH、DA的变化与中医证型之间的相关规律性，探讨中医证型的客观化指标。

Correlation between Serum Thyroid Hormone and Dopamine Levels and Chinese Medicine Syndrome Types

Objective To analyze the correlation between changes of thyroid hormone（TH）,dopamine（DA） and Chinese medicine syndrome types by detecting contents of serum TH and DA in insomnia,thus to explore objective indices of Chinese medicine syndrome types.Methods Insomnia patients were assigned to four Chinese medicine syndrome types groups,covering depressed Gan transforming into fire,internal disturbance by phlegm-heat,excessive fire due to yin deficiency,and Xin-Pi deficiency.One healthy control group was set up.Each group consisted of 30 patients or subjects.Serum DA content was determined using spectrophotofluorimetry.Serum levels of 3,5,3＇-triiodothyronine（T3） and tetraiodothyronine（T4） were detected using radioimmunoassay（RIA）.Results The serum leuels of DA and TH showed difference among groups at various levels.The serum DA level was sequenced from high to low as the control groupthe depressed Gan transforming into fire groupthe excessive fire due to yin deficiency groupthe internal disturbance by phlegm-heat groupthe Xin-Pi deficiency group.The serum TH level was sequenced from high to low as the excessive fire due to yin deficiency groupthe depressed Gan transforming into fire groupthe internal disturbance by phlegm-heat groupthe control groupthe Xin-Pi deficiency group.Conclusions Serum DA levels in insomnia patients were in line with the disease course and the dynamic change from sthenia to asthenia in Chinese syndrome types.Serum DA levels,as one of pathological factors constituting the sthenia syndrome or the asthenia syndrome,may be taken as an objective indicator in Chinese medicine syndrome typing.