多囊卵巢综合征的中医证候分布及其规律探讨

目的 探讨多囊卵巢综合征(PCOS)中医证型及相关临床症状的分布规律，以及PCOS相关参数的改变与中医证候分类可能存在的联系，指导选用与证型紧密相关的指标评价疗效。

Distribution of Chinese Medicine Syndrome Patterns and Its Laws in Patients with Polycystic Ovarian Syndrome

Objective To study the distribution laws of the Chinese medicine syndrome patterns and its correlated symptoms in patients with polycystic ovarian syndrome（PCOS）,and the possible correlation between Chinese medicine syndrome patterns and PCOS associated parameters,thus to provide a guidance for selecting proper indices in curative effectiveness assessment.Methods Using clinical epidemiological methods and mathematical statistics,the Chinese medicine syndrome patterns were studied in 228 PCOS patients.The distribution features of Chinese medicine syndrome patterns were summarized.Results Shen-deficiency blood-stasis syndrome was the most frequently seen in PCOS patients,followed by Pi-deficiency phlegm-dampness syndrome,Pi-Shen yang-deficiency syndrome,and Shen-yin deficiency syndrome.Positive correlation existed between serum levels of follicle stimulating hormone（FSH） and Pi-Shen yang-deficiency syndrome.Positive correlation existed between fasting blood sugar（FBS）,waist to hip ratio（WHR）,body mass index（BMI）,fasting insulin（FIN）,and Hirsutism score and Pi-deficiency phlegm-dampness syndrome.Positive correlation existed between serum levels of prolactin（PRL）,estradiol（E2） and qi stagnancy and blood stasis syndrome.Positive correlation existed between serum progesterone（PRG） level,FSH,FIN,BMI,acne score and Gan stagnancy and blood heat syndrome.Positive correlation existed between luteinizing hormone（LH） and Shen-deficiency blood-stasis syndrome.Besides,LH/FSH3 was possibly more frequently seen in Pi-deficiency phlegm-dampness syndrome and Pi-Shen yang-deficiency syndrome.Family heritability could be seen in each syndrome patterns.Among them,female heritability was more often seen in Shen-deficiency blood-stasis syndrome,while male heritability was more often seen in Shen-yin deficiency syndrome.Conclusions Shen-deficiency blood-stasis syndrome,Pi-deficiency phlegm-dampness syndrome,Pi-Shen yang-deficiency syndrome,and Shen-yin deficiency syndrome were most frequently seen in PCOS patients.The sex hormones（including 6 items）,FBS,FIN,WHR and BMI,etc.were correlated with each Chinese medicine syndrome pattern to various extents,which could be taken as reference in Chinese medicine syndrome differentiation.