排毒保肾丸治疗慢性肾功能衰竭的临床观察

目的 评估排毒保肾丸（即大黄虫丸加减）对延缓慢性肾功能衰竭（chronic renal failure, CRF）2、3期进程的影响。方法 将283例慢性肾衰2、3期患者分为2组，治疗组151例（用排毒保肾丸3g，每天2次口服治疗）；对照组132例（用包醛氧化淀粉酶胶囊每次 5～10粒，每日3次餐后服）； 两组均2个月为1个疗程，治疗1、2个疗程后观察生活质量、临床症状评分及血清肌酐、尿素氮、内生肌酐清除率指标变化。结果 两组临床症状积分、生活质量评分比较差异有统计学意义（t值分别为29.49、9.8，P<0.01）。治疗组总有效率70.86%(107/151例），对照组总有效率44.70%（59/132例），两组比较差异有统计学意义（χ²=18.69，P<0.01），治疗前两组血清肌酐、尿素氮、内生肌酐清除率比较，差异无统计学意义（P<0.05）；治疗1、2个疗程后两组比较，差异有统计学意义（P<0.05，P<0.01）。结论 排毒保肾丸对延缓慢性肾功能衰竭进程有效，能提高患者生活质量。

Effect of Paidu Baoshen Pill in Retarding the Progression of Chronic Renal Failure

OBJECTIVE: To assess the impact of Paidu Baoshen Pill (PBP, modified Dahuang Zhechong Pill), in retarding the procession of chronic renal failure (CRF) of stage II-III. METHODS: The 283 patients of CRF stage II-III were randomly assigned to two groups, 151 patients in the treatment group treated with oral administration of PBP 3 g twice a day, and 132 patients in the control group with oxidative amylase aldehyde enveloped capsule 5-10 capsules thrice a day after meal. The course for both groups was 2 months, and the changes after 1 or 2 courses treatment in scoring of quality of life (QOL) and clinical symptoms, also in laboratory indexes including serum levels of creatinine (Cr), urea nitrogen (UN), and intrinsic creatinine clearance rate were observed. RESULTS: The total effective rate was 70. 86% (107/151 cases) in the treatment group and 44.70% (59/132 cases) in the control group, showing significant difference between them (X2 = 18.69, P < 0.01). Significant differences between groups were also shown in comparisons of scores of QOL and clinical symptoms after treatment. Inter-group comparison showed no difference in all the three indexes detected before treatment, but they did show statistical significance respectively after 1 and 2 courses of treatment (P < 0.05 and P < 0.01). CONCLUSION: PBP could effectively retard the progression of chronic renal failure and significantly improve the QOL of patients.