黄芪注射液辅助治疗老年肺结核的疗效观察

目的：观察黄芪注射液辅助抗结核药物治疗老年肺结核的临床疗效。方法：将76例痰菌阳性的老年肺结核患者按入院先后顺序随机分为黄芪组（39例）及化疗组（37例），两组初治肺结核采用HRE（S）Z，复治肺结核采用KHZ1321TH化疗方案。黄芪组辅黄芪注射液20ml加5％葡萄糖注射液500ml中静脉滴注，每日1次，疗程2个月，治疗前及治疗2个月后分别观察病灶范围、痰菌及红细胞免疫功能等变化，并以30名健康人的红细胞免疫指标作对照。结果：两组患者红细胞免疫功能均低于健康人（P＜0.01），两组治疗前后红细胞C3b花环率（RBC－C3bRR）比较均有升高，黄芪组RBC－C3bRR升高幅度优于化疗组（P<0.01）。黄芪组和对照组治疗2个月后X线胸片吸收总有效率分别为84.6%、67.5％，痰菌阴转率分别为79.4%、56.7％（P＜0.05）。结论：黄芪注射液具有增强老年肺结核患者的红细胞免疫功能的作用，能提高老年肺结核的治疗效果。

Observation on Effect of Supplementary Treatment by Astragalus Injection in Treating Senile Pulmonary Tuberculosis Patients

Objective: To observe the clinical therapeutic supplementary effect of Astragalus injection (ASI) as anti tuberculosis agents in treating senile tuberculosis (ST). Methods: Seventy six ST patients were divided according to their hospitalization order into two groups randomly, 39 in the ASI group and 37 in the control group. The anti tuberculosis regimen applied on all patients were HRE (S)Z for first treated patients and KHZ 1321 TH for re treated patients. In the ASI group, ASI was given additionally by adding ASI 20 ml into 500 ml 5% glucose solution for intravenous dripping, once a day. The therapeutic course was 2 months. The changes of focal size, bacteria in sputum, and erythrocyte immune function (EIF) were observed before and after treatment, and the EIF obtained from 30 healthy subjects was taken for control. Results: EIF in patients of both groups was lower than that in healthy subjects (P<0 01). Rosette rate of RBC C 3 b receptor in both groups was all increased after treatment, the increment was higher in the ASI group than that in the control group significantly (P<0 01). After 2 months ASI treatment, the effective rate of focal absorption examined by X ray was 84.6% and the negative conversion rate of bacteria in sputum was 79.4%. Conclusion: ASI has the effect of elevating erythrocyte immunity in senile pulmonary tuberculosis patient, it is able to enhance the therapeutic effect of treatment.