肾病合剂对阿霉素肾病大鼠肝组织白蛋白基因表达影响的实验研究

目的：探讨肾病合剂对阿霉素肾病大鼠肝组织白蛋白基因表达的作用。方法：建立阿霉素肾病大鼠模型，采用Northen杂交及Dot-blot定量分析，观察肝组织白蛋白mRNA的表达水平。结果：肾病合剂组大鼠肝组织白蛋白mRNA表达均明显高于模型组及正常组（P＜0．05）。结论：肾病合剂可上调阿霉素肾病大鼠肝组织白蛋白mRNA的表达水平，促进白蛋白合成。

Study on Effect of Nephropathy Mixture on Genetic Expression of Liver Albumin in Rats with Adriamycin-Induced Nephrotic Syndrome

Objective: To explore the effect of Nephropathy mixture on genetic expression of liver albunin in rats with adriamycin induced nephrotic syndrome. Methods: The rat model of adriamycin induced nephrotic syndrome was established and the liver albumin mRNA expression level was observed with Northern hybridization and Dot blot quantitative analysis. Results: The liver albumin mRNA expression level in the Nephropathy Mixture treated group was significantly higher than that in the model group and the normal control group (P<0 05). Conclusion: Nephropathy Mixture could up regulate the liver albumin mRNA expression level and promote the synthesis of albumin in rats with adriamycin induced nephrotic syndrome.