米非司酮与氨甲喋呤配合中药治疗异位妊娠的临床观察

目的：将两种不同药物治疗异位妊娠的方法进行比较，以寻找一种简捷、有效、副作用小的方法。方法：将114例异位妊娠患者分为口服米非司酮组（A组）56例，肌肉注射氨甲喋呤（MTX）组（B组）58例，两组均加服中药，观察比较疗效。结果：治疗成功率A组为82．14％，B组为70．69％，差异无显著性（P＞0．05）；治疗成功所需时间A组为（14．54±5．87）天，B组为（9．00±5．09）天，两组比较差异有显著性意义（P＜0．01）。两组在恶心、呕吐、腹泻、肝功能异常及白细胞降低等副反应方面差异无显著性（P＞0．05）；而月经复潮时间A组为（43．43±1．77）天，B组为（38．38±1．13）天，两组比较差异有显著性（P＜0．05）。结论：米非司酮与氨甲喋呤配伍中药治疗异位妊娠两者疗效相似，而后者显效更快，致月经延迟的副作用较轻。

Observation on Treatment of Ectopic Pregnancy by Combination Therapy of Chinese Herbal Medicine with Mifepristone or Methotrexate

OBJECTIVE: To find a simpler, effectiver with less side-effect method for treatment of ectopic pregnancy. METHODS: One hundred and fourteen patients of ectopic pregnancy were divided into two groups, the 56 patients in Group A were treated with Mifepristone and Chinese herbal medicine (CHM), and 58 patients in Group B were treated with Methotrexate and CHM. The therapeutic effect in both groups was observed and compared. RESULTS: The rate of success in Group A was 82.14% and in Group B 70.69%, comparison between them showed no significance (P > 0.05). Time for successful treatment was 14.54 +/- 5.87 days in Group A and 9.00 +/- 5.09 days in Group B, comparison of them showed significant difference (P < 0.01). Insignificance revealed in comparison between the occurrence of side-effects for the groups, such as nausea, vomiting, diarrhea, liver dysfunction and lowering of white blood cells, but significance was shown in re-menstruation time (43.43 +/- 1.77 days vs 38.38 +/- 1.13 days, P < 0.05). CONCLUSION: Treatments of combined CHM with Mifepristone or Methotrexate showed similar therapeutic effect in treating ectopic pregnancy, but the latter showed a quicker initiation and less side-effects in delaying the re-menstruation time.