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补肾方防治地塞米松致雄性大鼠骨质疏松及其生化机制探讨
引用本文:沈培芝,陈东煜,张戈,史万忠,徐宇,石印玉.补肾方防治地塞米松致雄性大鼠骨质疏松及其生化机制探讨[J].中国中西医结合杂志,1998,18(5):290-292.
作者姓名:沈培芝  陈东煜  张戈  史万忠  徐宇  石印玉
作者单位:上海市中医药研究院骨伤科研究所!上海200032(沈培芝,张戈,史万忠,徐宇,石印玉),上海市宝冶医院(陈东煜)
基金项目:国家九五攻关资助项目!(No 96 - 90 6 - 0 9- 0 5 )
摘    要:研究补肾方预防和治疗地塞米松致雄性大鼠骨质疏松的疗铲,并探讨其生化机制。方法:采用12月龄SD雄性大鼠46只,随机分组给药,18周后分别测定全身骨密度,股骨抗弯强度以及血清中骨下素,甲状旁腺素,睾酮,雌二醇的水平。结果;全身骨密度,股骨抗弯强度预防组显著高于地塞米松组,与空白对照组比较未见明显差异;

关 键 词:补肾方  骨质疏松  糖皮质激素  防治

Study on Efficacy of Chinese Kidney-Tonifying Recipe in Male Rats with Osteoporosis Induced by Dexamethasone and Its Mechanism
Authors:Shen Peizhi  Chen Dongyu  Zhang Ge  Institute of Traumatology and Orthopedics  Shanghai Academy of TCM  Shanghai
Abstract:Objective: To study the efficacy of traditional Chinese Kidney Tonifying Recipe (KTR) in male rats with osteoporosis induced by dexamethasone (DM) and its mechanism. Methods: Forty six male Sprague Dawley rats at 12 months of age were chosen: they were divided into four groups and KTR and DM were administered appropriately for 18 weeks. General bone mineral density, femur bending strength, serum BGP,serum PTH and serum E 2 were measured. Results: General bone mineral density, femur bending strength in KTR prevention group were significantly higher than those in DM group (P<0 01)and the same with those in normal control group (P>0 05). General bone mineral density, femur bending strength in KTR treatment group were higher than those in DM group (P<0 05), and lower than those in normal control group. Compared with DM group, level of serum T in KTR prevention group and KTR treatment group increased (P<0 05) and level of serum PTH in those two groups decreased (P<0 05). But in comparison with DM group, level of serum E 2 and serum BGP in the above mentioned two groups was unchanged (P>0 05). Conclusions: The data indicated that traditional Chinese Kidney Tonifying Recipe could prevent and treat osteoporosis in male rats induced by DM.
Keywords:Kidney tonifying recipe  osteoporosis  gluco  corticoid
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