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麝香保心丸减轻自发性高血压大鼠心肌纤维化的研究
引用本文:武多娇,洪华山,江琼.麝香保心丸减轻自发性高血压大鼠心肌纤维化的研究[J].中国中西医结合杂志,2005,25(4):350-353.
作者姓名:武多娇  洪华山  江琼
作者单位:福建医科大学附属协和医院心内科,福建省冠心病研究所,福州,350001
摘    要:目的 探讨麝香保心丸对自发性高血压大鼠(SHR)心肌纤维化的作用及其可能的机制。方法 将12周龄SHR大鼠分为麝香保心丸治疗组、苯那普利阳性药物对照组及高血压模型对照组,研究麝香保心丸对治疗12周后的SHR大鼠收缩压(SBP)、左室重量(LVM)、左室重量指数(LVMI)、左室心肌胶原含量及细胞外基质纤连蛋白(fibronectin,FN)、层粘连蛋白(1aminin,LN)、心脏成纤维细胞(cardiac fibroblast,cFb)和转化生长因子-β1(TGF-β1)表达的影响。结果 麝香保心丸对SHR无明显降压作用,但与苯那普利一样可降低LVM、LVMI、心肌胶原含量(P<0.05)。麝香保心丸可明显降低心肌LN、FN含量、心脏成纤维细胞数目和转化生长因子-β1(TGF-β1)的表达(P<0.05)。结论 麝香保心丸具有独立降压以外的防治SHR心肌纤维化作用,其机制可能与减少心肌TGF-β1表达和心脏成纤维细胞数目,减少心肌胶原合成及细胞外基质沉积等因素有关。

关 键 词:麝香保心丸  心肌纤维化  转化生长因子-β1(TGF-β1)  自发性高血压大鼠(SHR)  TGF-β1表达  心脏成纤维细胞  细胞外基质沉积  SHR大鼠  左室重量指数  苯那普利  胶原含量  细胞数目  高血压模型  层粘连蛋白  纤维化作用  阳性药物
修稿时间:2004年11月29

Effect of Shexiang Baoxin Pill in Alleviating Myocardial Fibrosis in Spontaneous Hypertensive Rats
Authors:WU Duo-jiao  HONG Hua-shan and JIANG Qiong
Abstract:OBJECTIVE: To investigate the effects and mechanisms of Shexiang Baoxin Pill (SBP) on myocardial fibrosis in spontaneous hypertensive rats (SHR). METHODS: SHR of 12 weeks old were divided into the SBP group, the control group (treated with benazepril) and the model control group. The effects on such indexes as systolic blood pressure (SBP), left ventricular mass (LVM), left ventricular mass index (LVMI), content of myocardial collagen (MC) in left ventricle, extracellular matrix fibronectin (FN), laminin (LN), cardiac fibroblast (cFb) and transforming growth factor-beta1 (TGF-beta1) were determined after 12 weeks of treatment. RESULTS: SBP had no marked pressure depressive effect, but had the effect similar to that of benazepril in reducing the level of LVM, LVMI and content of MC (P < 0.05), as well as the content of LN, FN in myocardium, cFb count and TGF-beta1 expression (P < 0.05). CONCLUSION: SBP can prevent and treat myocardial fibrosis, whose action is independent of its hypotensive effect. The mechanism may be associated with such factors as the decrease of MC synthesis in left ventricle and the deposition of extracellular matrix.
Keywords:Shexiang Baoxin Pill  spontaneous hypertensive rats  cardiac fibroblast  transforming growth factor  fibroblast
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