扶正保真汤对恶性肿瘤放、化疗增效作用的临床与实验研究

目的：探讨扶正保真汤对恶性肿瘤放、化疗的增效作用机理。方法：１１７例恶性肿瘤患者予化疗或（和）放疗，其中５５例加扶正保真汤治疗（Ａ组），与３０例加卢芪扶正冲剂治疗（Ｂ组）及３２例单纯放、化疗（Ｃ组）比较、并进行对荷瘤小鼠化疗增效机理研究。结果：临床近期有效率（ＣＲ＋ＰＲ）：Ａ、Ｂ、Ｃ组依次分别为６３．６％、４３．３％、３７．５％，以Ａ组为佳（Ｐ〈０．０５）；生存质量亦以Ａ组为佳（Ｐ〈０．０５）；治

Clinical and Experimental Study on Fuzheng Baozhen Decoction Enhancing Effect of Radio and Chemotherapy for Malignant Tumors

objective To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy, 55 cases treated together with FZBZD( group A), comparing with 30 cases treated with radio and chemotherapy plus Zhenqi Fuzheng Granules (group B) and 32 cases radio and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy on transplanted human lung adenocarcinoma (SPC A 1) and sarcoma (S 180 ) bearing mice was conducted. Results: Effective rates (CR PR) of group A, B, C were 63.6%,43.3%,37.5% respectively ,that of group A was the best (P<0 05). The survival quality of life was improved best in group A (P<0 05). After being treated, the level of the peripheral blood (WBC, Hb, PLT) of group A was the highest (P<0 05); CD 3, CD 4, NK activity, interleukin 2 were also improved significantly in group A (P<0 01). Animal experiment showed that FZBZD could improve chemotherapy effect of inhibitory action on tumor growth (P<0 01), increase cAMP/cGMP ratio (P<0 01) by adding cAMP level in cancer tissue, and enhance of G 0/G 1 phase cells and decrease S phase cells. Conclusions: FZBZD inhibited tumor growth and enhanced the effect of radio and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and stagnating tumor cells in G 0/G 1 phase.