高血压病左心室肥厚患者血浆P物质水平的变化及活血祛痰治法的影响

目的：探讨血浆Ｐ物质与高血压病左心室肥厚的关系以及活血祛痰治法对其影响。方法：免疫法检测左心室肥厚（ＥＨ－ＬＶＨ）患者用活血痰法治疗前一血浆ＳＰ水平的变化。同时检测ＥＨ－ＬＶＨ患者治疗前后左心室指数、平均动脉压、血浆肾素活性及血管紧张素Ⅱ浓度等的变化。结果、ＥＨ－ＬＶＨ患者血浆ＳＰ水平显著下降，与高血压无左心室肥厚患者及健康人组比较有显著性差异；ＰＲＡ及ＡｎｇⅡ浓度明显高于健康人组。经活血祛痰法治

Study on Changes of Plasma Substance P in Essential Hypertension with Left Ventricular Hypertrophy Patients and the Effect of Promoting Blood Circulation and Eliminating Phlegm

OBJECTIVE: Exploring the relationship between the plasma substance P(SP) and essential hypertension with left ventricular hypertrophy (EH-LVH) and the effect of promoting blood circulation and eliminating phlegm. METHODS: Before and after treatment, the changes of SP in patients wiith EH-LVH were measured by radioimmunoassay. Meanwhile, the changes of plasma renin activity (PRA), angiotension II (Ang II), left ventricular mass index (LVMI) and mean arterial pressure (MAP) were measured. RESULTS: The level of plasma SP in patients with EH-LVH was markedly lower than that of patients without EH-NLVH and healthy subjects (P < 0.001); the levels of PRA and Ang II were higher than those in control group (P < 0.01 or < 0.05). After treatment, the level of SP was significantly increased, while LVMI, MAP, PRA and Ang II were significantly decrease (P < 0.01 or < 0.05). The levels between SP and LVMI, MAP, PRA, Ang II were markedly negative correlated (P < 0.01) while levels between LVMI and PRA, Ang II were markedly positive correlated. CONCLUSIONS: The SP may be involved in the pathogenesis of EH-LVH; the mechanism of promoting blood circulation and eliminating phlegm reversing LVH might be related to its increasing the plasma SP.