针刺三阴交的PET脑功能研究

目的探讨针刺三阴交的中枢作用机制。方法利用正电子发射断层摄影技术（positron emission tomograph，PET）对6例女性健康志愿者行针刺右侧三阴交前后的垲氟标记脱氧葡萄糖（^18F-FDG）脑功能成像，用统计参数图（Statistical parametric mapping，SPM）方法进行分析，获得针刺三阴交引起的脑内葡萄糖代谢变化区域。结果对侧第一躯体感觉区，对侧第一躯体运动区，双侧辅助运动区（BA6）和对侧前辅助运动区（BA8）、前扣带回（BA24、BA32）、双侧背外侧前额叶（BA9）和对侧中间前额叶（BA10）葡萄糖代谢增加。枕叶舌回（BA17、BA18）、海马和多个马旁回（BA28、BA35、BA30）葡萄糖代谢降低。结论三阴交穴位的临床作用与针刺后脑葡萄糖代谢变化的脑功能区所施控的功能具有良好的对应性，说明大脑在针刺三阴交对机体的调节中起重要作用，因此大脑可能是穴位治疗疾病的中枢基础。

Research on Effect of Acupuncture at Sanyinjiao on Brain Function by Means of Positron Emission Tomographic Imaging

Objective To explore the mechanism of puncturing at Sanyinjiao (SP6) on modulatory function of central nerve system. Methods Positron emission tomography (PET) was performed, using 18 F-FDG as contrast medium, in six healthy female volunteers before and after puncturing right SP6 to detect the cerebral districts with changed glucose metabolism, using statistical parametric mapping (SPM) analysis. Results Glucose metabolism was increased in contralateral primary somatosensory cortex, primary somatic motor cortex, pre-supplementary motor cortex (BA8), and medial prefrontal cortex (BA10), bilateral supplementary motor cortex (BA6), anterior cingulate gyrus (BA24, BA32), and dorsolateral prefrontal cortex (BA9), while glucose metabolism was decreased in lingual gyrus (BA17,18), hippocampus and parahippocampal gyrus (BA28,BA35,BA30). Conclusion Functions of cerebral districts with changed glucose metabolism after puncturing SP6 was well parallels to the clinical effect of puncturing SP6, illustrating the brain plays a great role in the body regulation of acupuncture at SP6, which possibly was the central foundation of acupuncture therapy.