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参松养心胶囊对冠心病室性早搏疗效及心脏自主神经功能的影响
引用本文:谷春华,吴以岭,田书彦,高学东,齐晓琳,贾振华,杨立波,李云鹏,徐贵成.参松养心胶囊对冠心病室性早搏疗效及心脏自主神经功能的影响[J].中国中西医结合杂志,2005,25(9):783-786.
作者姓名:谷春华  吴以岭  田书彦  高学东  齐晓琳  贾振华  杨立波  李云鹏  徐贵成
作者单位:1. 河北以岭医药研究院,石家庄,050035
2. 河北医科大学医药研究院
3. 中国中医研究院广安门医院
摘    要:目的 观察参松养心胶囊对冠心病室性早搏(气阴两虚、心络瘀阻型心悸)疗效及心脏自主神经功能的影响。方法 采用随机双盲、平行对照法按3:1比例随机分组,与心律宁片(苦参总碱)对照观察,病例完成治疗组165例,对照组56例,疗程均为4周。结果 两组冠心病室性早搏和中医证候疗效比较,治疗组高于对照组(P〈0.01)。治疗后两组心率变异(HRV)和QT离散度(QTd)均有一定的改善;两组间SDNN、SDANN、SDNN Index、PNN50变化值比较差异有显著性(P〈0.05,P〈0.01),治疗组疗效高于对照组。结论 参松养心胶囊对冠心病室性早博和中医证候有明显疗效,对心脏自主神经功能活动有明显改善作用。

关 键 词:参松养心胶囊  心脏自主神经功能  心率变异  冠心病  室性早搏  疗效比较  自主神经功能活动  中医证候  SDNN  QT离散度
收稿时间:2005-04-27
修稿时间:2005-06-02

Effect of Shensong Yangxin Capsule on Ventricular Premature Beat and Cardiovascular Autonomic Nervous Function in Patients with Coronary Heart Disease
Authors:GU Chun-hu  WU Yi-ling  Tian Shu-yan
Institution:Yiling Medicinal Academy, Shijiazhuang 050035
Abstract:OBJECTIVE: To observe the clinical efficacy of shensong yangxin capsule (SYC) on ventricular premature beat (VPB) differentiated in TCM as palpitation of Qi-yin deficiency syndrome or Xin collateral stagnation syndrome, and cardiovascular autonomic nervous function in patients with coronary heart disease (CHD). METHODS: The randomized, double-blind, parallel contrast method was adopted, patients were randomly assigned by 3:1 ratio into two groups. One hundred and sixty-five patients in SYC treated group and 56 in the control group (treated with Xinlvning tablet), and the therapeutic course for both groups was 4 weeks. RESULTS: The clinical efficacy on VPB and in improving TCM syndromes was better in SYC group than that in the control group (P < 0.01). After treatment, the heart rate variability (HRV) and QT dispersion in the two groups were improved in a certain degree. The changes of SDNN, SDANN, SDNN Index and PNN50 in the two groups were significantly different (P < 0.05, P < 0.01), the efficacy in the treated group was superior to that in the control group. CONCLUSION: SYC has definite effect on VPB and TCM Syndromes, it can obviously meliorate the activity of cardiovascular autonomic nervous system in the patients with CHD.
Keywords:Shensong Yangxin capsule  cardiovascular autonomic nervous function  heart rate variability  coronary heart disease  ventricular premature beat
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