抗炎灵对腹部外科全身炎性反应综合征和多器官功能不全综合征患者细胞因子和C-反应蛋白作用的研究

目的：观察抗炎灵对腹部外科全身炎性反应综合征和多器官功能不全综合征（SIRS／MODS）的治疗作用。方法：以腹部外科术后SIRS／MODS82例患者为研究 对象，按入院时间分为两组：对照组47例，抗炎灵治疗组35例。分别于术后1、3及7天观察血清C－反应蛋白（CRP）和血浆肿瘤坏死因子－α（TNF-α）、白细胞介素－6（IL－6）的含量并进行比较。结果：血清CRP和血浆 TNF－α和IL－6等指标两组术后均逐渐下降，第3天时两组比较差异有显著性（P＜0.05)，治疗组下降明显加快。结论：抗炎灵能抑制炎症介质释放，减轻炎性反应，有效地治疗腹部外科SIRS／MODS。

Study for Effect of Kangyanling on Cytokine and C-Reactive Protein in Patients of Systemic Inflammatory Reaction Syndrome and Multi-Organ Dysfunction Syndrome after Abdominal Surgery

OBJECTIVE: To observe the clinical effect and mechanism of Kangyanling (KYL) in treating patients with systemic inflammatory reaction syndrome and multi-organ dysfunction syndrome (SIRS/MODS) after abdominal surgery. METHODS: Eighty-two patients of SIRS/MODS after abdominal surgery were divided into two groups according to admission time, the KYL treated group (n = 35) and the control group (n = 47). The levels of serum C-reactive protein (CRP), plasma tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were measured at the 1st, 3rd and 7th day post-operationally. RESULTS: The levels of CRP, TNF-alpha and IL-6 decreased gradually after surgical operation in both groups, but the reducing velocity was shorter in the KYL group than that in the control group, so the comparison of the levels in the two group showed significant difference on the 3rd day after operation (P < 0.05). CONCLUSION: KYL could inhibit the release of inflammatory mediator and relieve the inflammatory response so as to treat post-operational SIRS/MODS effectively.