双花喷雾剂治疗小儿上呼吸道感染临床与实验研究

目的：观察双花喷雾剂治疗小儿上呼吸道感染的疗效，探讨其作用机理。方法：将２７６例患儿随机分为两组，治疗组用双花喷雾剂，对照组用双黄连气雾剂；动物实验观察双花喷雾剂抗炎、抗病毒作用。结果：双花喷雾剂治疗总有效率９９．０３％，痊愈率６５．３８％；对照组总有效率９４．１１％，痊愈率４４．１２％，两组总有效率比较差异有显著性意义（Ｐ〈０．０１），治疗组疗效优于对照组。实验研究表明：双花喷雾剂能明显抑制二甲

Clinical and Experimental Study on Shuanghua Aerosol in Treating Infantile Upper Respiratory Tract Infection

OBJECTIVE: To study the effect and mechanism of Shuanghua aerosol (SHA) in treating infantile upper respiratory tract infection (IURTI). METHODS: In the clinical study, 276 cases of IURTI were randomly divided into two groups. The treated group was treated with SHA and the control group was treated with Shuanghuanglian aerosol (SHLA). In the experimental study, the effect of SHA on anti-inflammatory and anti-viral were observed. RESULTS: The clinical total effective rate of SHA was 99.03% and its cure rate 65.38%, while those of the SHLA was 94.11% and 44.12% respectively, significant difference was shown between the two groups (P < 0.01). Experimental study showed that SHA could inhibit the xylol induced ear swelling and the egg white induced paw swelling in mice obviously, suppress the proliferation of influenza virus in rat's lung. CONCLUSION: SHA has obvious anti-inflammatory and anti-viral effect, and has good curative effect in treating IURTI.