| 多发梗塞性痴呆大鼠模型的改进与应用 |
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| 引用本文： | 梅建勋,张云岭,张伯礼.多发梗塞性痴呆大鼠模型的改进与应用[J].中国中西医结合杂志,2000,20(2):113-115. |
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| 作者姓名： | 梅建勋 张云岭 张伯礼 |
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| 作者单位： | 天津中医学院!天津300193(梅建勋，张伯礼)，北京中医药大学(张云岭) |
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| 基金项目： | 国家九五科技攻关项目 !No .96 - 90 6 - 0 9- 0 3 |
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| 摘 要： | 目的：对多发梗塞性痴呆大鼠模型进行方法学改进，以此模型对健脑益智冲剂进行药效学观察。方法：从颈外动脉逆行插管注入血栓栓子造模，观察行为学和病理形态学的影响。结果：造模后脑内存在广泛而多发的梗塞灶，学习记忆能力明显下降（Ｐ〈０．０１，Ｐ〈０．０５），中药健脑益冲剂和喜得镇（Ｈy－dergine）药物干预后，上述发迹得以明显改善。结论：此模型是进行多发梗塞性痴呆基础研究和筛造新药的理想模型。
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| 关 键 词： | 梗塞性痴呆 学习记忆 痴呆 动物模型 |
Improvement and Application of Multi Infarct Dementia Model in Rats |
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| Authors: | MEI Jianxun |
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| Abstract: | To improve the method of inducing the multi infarct dementia (MID) model in rats to observe the pharmacodynamic effect of Jiannao Yizhi (JNYZ) granule on MID. Methods: Retrograde injection with the homologous embolus through the external carotid artery initiated the multi infarct dementia in rats. The experiment of behavior and morphology were conducted. Results: The extensive and multiple foci of infarction and the obviously declining ability of learning and memory were observed in the model group; the action of JNYZ granule and hydergine could obviously improve them. Conclusion: This model is useful to carry out basic research and screen new drugs in treating MID. |
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| Keywords: | multi infarct dementia rat model learning and memory |
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