载脂蛋白E基因多态性与原发性高脂血症中医辨证的相关性研究 |
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引用本文: | 蒋卫民,唐蜀华,赖仁胜,谢玲,王石.载脂蛋白E基因多态性与原发性高脂血症中医辨证的相关性研究[J].中国中西医结合杂志,2006,26(1):38-41. |
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作者姓名: | 蒋卫民 唐蜀华 赖仁胜 谢玲 王石 |
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作者单位: | 1. 南京中医药大学第一附属医院心内科,南京210029 2. 南京中医药大学第一附属医院病理科 |
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摘 要: | 目的 探讨载脂蛋白E(ApoE)基因多态性与原发性高脂血症中医辨证的相关关系。方法 采用基因测序法检测102例高脂血症患者的ApoE基因型。结果 共检出5种基因型,分别是E2/2、E3/3、E4/4、E2/3、E3/4;肝肾阴虚证E3/4+E4/4基因型频率和e4等位基因频率明显高于脾肾阳虚证和痰浊阻遏证(P〈0.05,P〈0.01),气滞血瘀证E3/4+E4/4基因型频率和ε4等位基因频率也明显高于痰浊阻遏证(P〈0.05)。结论 ApoE基因多态性与原发性高脂血症中医辨证具有一定的相关性。
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关 键 词: | 载脂蛋白E 基因多态性 高脂血症 中医证型 相关性 |
修稿时间: | 2005年5月25日 |
Study on the Relationship between Polymorphism of ApoE Gene and TCM Syndrome Type of Primary Hyperlipemia |
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Authors: | JIANG Wei-min TANG Shu-hu LAI Ren-sheng |
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Abstract: | OBJECTIVE: To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia. METHODS: ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing. RESULTS: A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05). CONCLUSION: Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia. |
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Keywords: | Apoprotein E gene polymorphism hyperlipemia syndrome type of TCM |
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