川芎嗪对免疫介导再生障碍性贫血小鼠骨髓细胞CD34抗原表达的影响 |
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引用本文: | 舒砚君,孙汉英,董凌莉,徐慧珍,路武,刘文励.川芎嗪对免疫介导再生障碍性贫血小鼠骨髓细胞CD34抗原表达的影响[J].中国中西医结合杂志,1998,18(2):107-108. |
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作者姓名: | 舒砚君 孙汉英 董凌莉 徐慧珍 路武 刘文励 |
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作者单位: | 同济医科大学附属同济医院!武汉430030 |
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基金项目: | 国家自然科学基金!39470883,湖北省自然科学基金!96J080 |
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摘 要: | 目的:探讨川芎嗪对免疫再生障碍性贫血(再障)小鼠骨髓细胞CD34抗原分子表达的影响。方法:建立免疫介导的再障小鼠模型,6.0Gy^60Coγ-射线照射和尾静脉输注淋巴细胞造成小鼠再障。分为正常组、再障组(对照组)、川芎嗪组,除正常组外均胃饲川芎嗪注射液4mg/次,1天2次,第10天用流式细胞仪检测各组小鼠骨髓细胞膜上CD34抗原表达量。结果:川芎嗪CD34抗原表达量的荧光强度(77.6±.6.5)
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关 键 词: | 川芎嗪 再生障碍性贫血 CD34抗原 |
Effect of Ligustrazine on CD34 Antigen Expression of Bone Marrow Cells in Immune-Mediated Aplastic Anemia Mice |
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Authors: | Shu Yanjun Sun Hanying Dong Lingli |
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Institution: | Tongji Hospital, Tongji Medical University, Wuhan 430030. |
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Abstract: | OBJECTIVE: To explore the effect of ligustrazine on CD34 antigen expression of bone marrow cells in immune-mediated aplastic anemia (AA) mice. METHODS: The model of immune aplastic anemia mice was induced by means of 6.0 Gy60Co gamma-ray irradiation and lymphocyte infusion through tail vein. The mice were divided into 3 groups: the normal group, the AA control group and the ligustrazine group. Mice of the ligustrazine group were fed by 4 mg of ligustrazine injection twice a day by gastrogavage. On the 10th day, CD34 antigen expression intensity of bone marrow cell membrane was measured by flow cytometer analysis system. RESULTS: CD34 antigen expression intensity of ligustrazine group was 77.6 +/- 6.5, with no statistic difference from that in the normal group (80.0 +/- 2.6), while that of the control group was much higher (68.6 +/- 4.5, P < 0.05). CONCLUSIONS: Ligustrazine could promote proliferation of stem and progenitor cell of AA mice through influencing on bone marrow micro-environment so as to increase the CD34 antigen expression of bone marrow cells. |
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Keywords: | ligustrazine aplastic anemia mice CD_(34) antigen expression |
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