黄芪注射液治疗充血性心力衰竭的疗效研究 |
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引用本文: | 周智林,俞娉,林玎,梁丽贞,林萍.黄芪注射液治疗充血性心力衰竭的疗效研究[J].中国中西医结合杂志,2001,21(10):747-749. |
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作者姓名: | 周智林 俞娉 林玎 梁丽贞 林萍 |
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作者单位: | 浙江省杭州市第三人民医院 |
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摘 要: | 目的:探讨黄芪注射液静脉滴注治疗充血性心力衰竭(简称CHE)的临床疗效及副作用。方法:属NYHA心功能分级为2-4级的住院CHF患者83例随机分为两组:治疗组用黄芪注射液40ml(生药80g)加入5%葡萄糖注射液500ml中静脉滴注,每日1次,疗程为2周,并随访1-6个月。对照组用硝酸甘油15mg加入5%葡萄糖注射液500ml中静脉滴注,每日1次,疗程亦为2周,同样随访1-6个月。结果:治疗组用黄芪治疗后1个月、6个月临床心功能改善显效率及总有效率分别为26.2%、78.6%,34.2%、81.6%,明显优于对照组(P<0.05,P<0.01)。两组治疗后的左室射血分数(LVEF)、左室短轴缩短率(FS)、二尖瓣快速充血期和心房收缩期血流速度(E/A)、每搏出量(SV)、心输出量(CO)及心脏指数(CI)均较治疗前有明显改善(P<0.05,P<0.01),但治疗组更优于对照组(P<0.05)。随访1-6个月治疗组心脏性事件发生率少于对照组(P<0.05)。结论:黄芪注射液可作为HF尤其重症CHF抢救的重要辅助药物之一。
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关 键 词: | 黄芪注射液 充血性心力衰竭 心功能分级 中医药疗法 治疗 疗效 |
修稿时间: | 2001年3月5日 |
Study on Effect of Astragalus Injection in Treating Congestive Heart Failure |
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Authors: | ZHOU Zhi lin YU Ping LIN Ding |
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Abstract: | OBJECTIVE: To observe the clinical efficacy and side-effects of Astragalus Injection (AI) in treating congestive heart failure (CHF). METHODS: Eighty-three patients of CHF with heart function of II-IV grade assessed by NYHA (New York Heart Association) classification were randomly divided into 2 groups. The 42 patients in the treated group were treated with AI 40 ml (equivalent to 80 g crude drug) by adding in 5% glucose solution 500 ml for intravenous dripping, once a day and the 41 patients in the control group were treated by nitrolingual injection 15 mg by adding in 5% glucose solution 500 ml for intravenous dripping once a day. The therapeutic course in both groups was 2 weeks and the patients were followed-up for 1-6 months. RESULTS: The clinical heart function improvement rate and the total effective rate in the treated group after 1 month treatment were 26.2% and 78.6%, and after 6 months were 34.2% and 81.6% respectively, which were superior to those in the control group significantly (P < 0.05 or P < 0.01). The levels of left ventricular ejection fraction (LVEF), fractional shortening of left ventricular short axis (FS), the ratio of maximum blood flow between the advanced and early atrial systole (E/A), stroke volume (SV), cardiac output (CO) and the cardiac index (CI) were all improved in both groups (P < 0.01 or P < 0.05), but better improvement was shown in the treated group. Follow-up study showed that the incidence of cardiac event was lower in the treated group than that in the control group (P < 0.05). CONCLUSION: AI can be took as one of the important auxiliary drugs for treatment of CHF especially in severe cases. |
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Keywords: | Astragalus injection congestive heart failure heart function classification |
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