| 冠脉舒对冠心病患者血浆组织型纤溶酶原激活物及其抑制物的影响 |
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| 引用本文： | 熊小忠,莫树松,祁述善,王钟林.冠脉舒对冠心病患者血浆组织型纤溶酶原激活物及其抑制物的影响[J].中国中西医结合杂志,1993(12):727-729,708,709. |
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| 作者姓名： | 熊小忠 莫树松 祁述善 王钟林 |
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| 作者单位： | 湖南医科大学附属第二医院心血管内科，湖南医科大学附属第二医院心血管内科，湖南医科大学附属第二医院心血管内科，湖南医科大学附属第二医院心血管内科 长沙 410011 研究生，长沙 410011导师，长沙 410011导师，长沙 410011导师 |
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| 摘 要： | 本课题研究中药冠脉舒对冠心病患者血浆组织型纤溶酶原激活物(t·PA)及其抑制物(PAI)的影响。将50例患者随机分为治疗组(30例)和对照组(20例),并与健康人对照。结果表明,同健康人比较,冠心病患者血浆t-PA活性明显降低(P<0.05),PAI活性明显升高(P<0.01)。经冠脉舒治疗后,t-PA活性升高(P<0.001),PAI活性降低(P<0.001)。提示冠脉舒能提高冠心病患者血浆纤溶活性。
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| 关 键 词： | 冠脉舒 冠心病 组织型纤溶酶原激活物 纤溶酶原激活物抑制物 |
Effects of Guan-Mai-Shu on Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor in the Plasma of Patients with Coronary Heart Disease |
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| Authors: | Xiong Xiao-zhong Mo Shu-song |
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| Abstract: | Effects of Guan-Mai-Shu (GMS), a traditional Chinese medicine preparation, on tissue-type
plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of patients
with coronary heart disease were studied. It was found that those patients had a significant decrease
in t-PA activity (P< 0.05) and a significant increase in PAI activity (P< 0.01) compared to healthy
subjects. After treatment of GMS, t-PA activity significantly increased (P< 0.001), while PAI
activity decreased (P< 0.001). These results indicated that GMS could raise t-PA activity and reduce
PAI activity in the plasma of patients with coronary heart disease. |
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| Keywords: | Guan-Mai-Shu coronary heart disease tissue-type plasminogen activator plasminogen activator inhibitor |
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