补肾生精汤对肾阳虚睾丸功能损害大鼠模型作用的实验研究

探讨补肾生精汤治疗男性不育症的作用机理。选用２５０ｇ左右的Ｗｉｓｔａｒ系雄性大鼠，每日灌喂腺嘌呤３０ｍｇ／１００ｇ体重，连续３０天，大鼠出现与人类肾阳虚相似的症状，生育力低下，睾丸生精功能障碍，血中促黄体生成激素、睾酮和皮质醇含量均比正常组大鼠显著降低。造模后，中药治疗组大鼠每日饮服补肾生精汤药液３ｍｌ／１００ｇ体重，连续服药１０天，间歇３天再服，共服药３０天。结果：中药治疗组大鼠肾阳虚症状明显改

Experimental Study on Effect of Bushen Shengjing Decoction on kidney Yang and Testicular Dysfunction in Rats

Objective: To explore the therapeutical mechanism of Bushen Shengjing Decoction (BSSJD) in treating infertility. Methods: Fed Wistar male rats with adenine 30mg/100g.d continuously for 30 days. The rats manifested the symptom which was similar to the human Kidney Yang Deficiency, the genitality dropped, the function of sperm-producing in the testis was disturbed, the contents of luteinizing hormone (LH), testosterone (T) and compound F (F) in blood were all lower than rats of normal group, P<0. 01. The model rats took the BSSJD 3 ml/100g .d (each ml contains crude drugs 2g)continuously for 10 dsys,interval for three days, then medicated again and total medication of BSSJD was 30 days. Resulta: The symptom of Kidney Yang Deficiency in rats was improved obviously, the genitality, sperm quality and function of sperm producing in testis were all enhanced obviously, so did the hormone level of LH, T, F in blood. Comparing to untreated control group, the difference was significant (P<0. 05). Conclusion: BSSJD has the function of reinforcing Yang and replenishing essence and regulate the endocrinological function.