补阳还五汤对球囊扩张主动脉后再狭窄其内皮PDGFR和SOD-1基因表达的探讨

目的：探讨补阳还五汤防治经皮控内冠脉成形术（ＰＴＣＡ）后再狭窄的消长机制。方法：仿ＰＴＣＡ术后再狭窄的新西兰兔模型２８只，以原位引物标记法测动脉内皮铜－锌超氧化物歧化酶（ＳＯＤ－１）及血小板衍化生长因子受体（ＰＤＧＦＲ）的基因表达，分析再狭窄消长机理。结果：主动脉球囊扩张术后７天，手术部位动脉内皮的ＳＯＤ－１基因表达增强，与对照组有显著差异（Ｐ〈０．０５）。而ＰＤＧＦＲｍＲＮＡ的表达则减弱，与对照

Study on Platelet-Derived Growth Factor mRNA and Copper-Zinc Superoxide Dismutase mRNA Expression Changes of Aortic Artery Endothelium with Restenosis after Aortic Artery Dilatation Treated with Buyang Huanwu Decoction

OBJECTIVE: To study on dynamic mechanism of restenosis after PTCA treated with Buyang Huanwu Decoction (BYHWD). METHODS: Twenty-eight male New Zealand rabbits with mimic restenosis after aortic artery dilatation were detected by prime in situ labeling in aortic endothelium. The items included gene expression of copper zinc superoxide dismutase (SOD-1) and platelet-derived growth factor receptor (PDGFR) mRNA to analyse dynamic mechanism of restenosis. RESULTS: Seven days after aortic artery dilatation, PDGFR mRNA of aortic endothelium decreased clearly. The comparison between experimental and the control group showed significant difference (P < 0.05). By the same condition, the gene expression of SOD-1 was increasing, which showed a significant difference with the control group (P < 0.05). CONCLUSIONS: BYHWD increased SOD-1 gene expression of artery endothelium, to improve oxygen feed for ischemia reperfusion in the same way, BYHWD suppressed PDGFR mRNA expression to control cellular pathological proliferation.