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济肾汤对糖尿病大鼠肾脏病变的影响
引用本文:黄翠玲,李才,邓义斌,王丽娟,赵丽艳.济肾汤对糖尿病大鼠肾脏病变的影响[J].中国中西医结合杂志,1997,17(11):676-678.
作者姓名:黄翠玲  李才  邓义斌  王丽娟  赵丽艳
作者单位:白求恩医科大学应用基础医学研究所
摘    要:目的:观察济肾汤地实验性糖尿病大鼠肾脏病变的改善作用。方法:将糖尿病大鼠4周后再随机分为3组,糖尿病组,糖尿病依那普利治疗组(依那普利用量为每日1mg/kg,作为阳性对照药)和糖尿病济肾汤治疗组(济肾汤用量为每日22.4g/kg),灌胃给药治疗8周。观察治疗前后肾脏变化,血清肌酐(SCr)尿素氮(BUN)血脂,尿微量白蛋白(Alb)β2-微球蛋白(β2-m)N-乙酰-β-D氨基葡萄糖苷酶(NAG)

关 键 词:济肾汤  糖尿病  肾脏病变

Effect of Jishentang on Renal Lesions in Diabetic Rats
Authors:C L Huang  C Li  Y B Deng
Institution:Institute of Preclinical Medicine, Norman Bethune University of Medical Sciences, Changchun.
Abstract:OBJECTIVE: To observe the ameliorative effect of Jishentang (JST) on renal lesions in experimental diabetic rats. METHODS: The diabetic rats were randomly divided into three groups: group with out treatment, group with enalapril treatment (the dose of enalapril was 1 mg/kg.d) and group with JST treatment (the dose of JST was 22.4 g/kg.d). The treatment lasted for 8 weeks. RESULTS: (1) JST treatment attenuated the renal hypertrophy and ratio of kidney and body weight (P < 0.01). (2) JST treatment reduced the levels of SCr and BUN and the levels of Alb, beta 2-m and the activity of NAG in urine in diabetic rats significantly (P < 0.01). The levels of TG and TCh decreased and the levels of HDL-C increased in the serum of the JST treated diabetic rats (P < 0.01). (3) The glomerular basement membrane thickening and volume density of PAS positive staining in mesangial area were significantly decreased in JST treated diabetic rats. CONCLUSIONS: JST exerted obvious ameliorative effect on renal function and structure in diabetic rats.
Keywords:Jishentang  diabetic rat  renal function  renal structure
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