济肾汤对糖尿病大鼠肾脏病变的影响 |
| |
引用本文: | 黄翠玲,李才,邓义斌,王丽娟,赵丽艳.济肾汤对糖尿病大鼠肾脏病变的影响[J].中国中西医结合杂志,1997,17(11):676-678. |
| |
作者姓名: | 黄翠玲 李才 邓义斌 王丽娟 赵丽艳 |
| |
作者单位: | 白求恩医科大学应用基础医学研究所 |
| |
摘 要: | 目的:观察济肾汤地实验性糖尿病大鼠肾脏病变的改善作用。方法:将糖尿病大鼠4周后再随机分为3组,糖尿病组,糖尿病依那普利治疗组(依那普利用量为每日1mg/kg,作为阳性对照药)和糖尿病济肾汤治疗组(济肾汤用量为每日22.4g/kg),灌胃给药治疗8周。观察治疗前后肾脏变化,血清肌酐(SCr)尿素氮(BUN)血脂,尿微量白蛋白(Alb)β2-微球蛋白(β2-m)N-乙酰-β-D氨基葡萄糖苷酶(NAG)
|
关 键 词: | 济肾汤 糖尿病 肾脏病变 |
Effect of Jishentang on Renal Lesions in Diabetic Rats |
| |
Authors: | C L Huang C Li Y B Deng |
| |
Institution: | Institute of Preclinical Medicine, Norman Bethune University of Medical Sciences, Changchun. |
| |
Abstract: | OBJECTIVE: To observe the ameliorative effect of Jishentang (JST) on renal lesions in experimental diabetic rats. METHODS: The diabetic rats were randomly divided into three groups: group with out treatment, group with enalapril treatment (the dose of enalapril was 1 mg/kg.d) and group with JST treatment (the dose of JST was 22.4 g/kg.d). The treatment lasted for 8 weeks. RESULTS: (1) JST treatment attenuated the renal hypertrophy and ratio of kidney and body weight (P < 0.01). (2) JST treatment reduced the levels of SCr and BUN and the levels of Alb, beta 2-m and the activity of NAG in urine in diabetic rats significantly (P < 0.01). The levels of TG and TCh decreased and the levels of HDL-C increased in the serum of the JST treated diabetic rats (P < 0.01). (3) The glomerular basement membrane thickening and volume density of PAS positive staining in mesangial area were significantly decreased in JST treated diabetic rats. CONCLUSIONS: JST exerted obvious ameliorative effect on renal function and structure in diabetic rats. |
| |
Keywords: | Jishentang diabetic rat renal function renal structure |
本文献已被 维普 等数据库收录! |
| 点击此处可从《中国中西医结合杂志》浏览原始摘要信息 |
| 点击此处可从《中国中西医结合杂志》下载免费的PDF全文 |