黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究

观察黄连素对高脂饮食大鼠胰岛素敏感性的影响。灌服黄连素前后采用葡萄糖－胰岛素耐量试验测量大鼠胰岛素敏感性，并测量空腹血糖、胰岛素、血脂及肌肉中甘油三酯含量等。１个月后，高脂饮食对照且的空腹血糖、胰岛素、血脂、肌肉中ＴＧ高于正常对照组，而肝糖原减少，胰岛素敏感性下降。

Experimental Study on Berberin Raised Insulin Sensitivity in Insulin Resistance Rat Models

To observe the effects of berberin on insulin sensitivity in high fat diet rats. Methods: Before and after ingesting berberin, glucose insulin tolerance test was used to measure the insulin sensitivity, and determining fasting blood glucose, insulin, blood lipid and muscle triglyceride content. Results: Compared with normal feeding rats, high fat feeding impaired insulin action (5. 02 ±1. 08 vs 8. 72± 0. 91, P<0. 005), decreased liver glycogen level and raised fasting blood glucose, insulin and blood lipid levels. Berberin and metformin improved insulin resistance (6. 31 ± 0. 95 and 6. 24± 0. 65) and liver glycogen level in insulin resistance models, but had no effect on blood glucose, insulin, lipid levels and muscle triglyceride depots. Conclusion: It is confirmed that berberincould raise insulin sensitivity of high fat diet rats similar to metformin.