Observation on Therapeutic Effect of Acupuncture and Medication for 30 Cases of Post-Stroke Depression

目的照观察针药结合与单纯西药治疗中风后抑郁症(PSD)的疗效及不良反应.方法采用开放性对照研究方法,将93例抑郁症患者随机分为三组,针药组30例、百忧解A组30例、百忧解B组33例.针药组口服百忧解20 mg/d并加以针刺,百忧解A组口服百忧解20 mg/d,百忧解B组口服百忧解20～40 mg/d;三组治疗时间均为42 d,以汉密尔顿抑郁量表(HAMD)及副反应观察量表(TESS)分别观察三组的疗效及不良反应.结果针药组有效率为86.7%,百忧解A组为63.3%,百忧解B组为87.9%,针药组疗效优于百忧解A组,与百忧解B组疗效差异无统计学意义(P＞0.05),但药物不良反应发生率百忧解B组高于针药组.结论药并用是脑卒中后抑郁症的一种疗效确切且副反应少的治疗方法.

Observation on therapeutic effect of acupuncture and medication for 30 cases of post-stroke depression

Objective To investigate the therapeutic effects and adverse reaction of acupuncture plus medication and single medication for post-stroke depression(PSD). Methods In an open control study, 93 cases of the patients with depression were randomly allocated to three groups: 30 cases in the acupuncture-medication group (AM), 30 cases in Prozac Group A (A), and 33 cases in Prozac Group B (B). The acupuncture-medication group was treated by oral administration of Prozac 20 mg/d plus acupuncture. Prozac Group A was treated by oral administration of Prozac 20 mg/d. Prozac Group B was treated by oral administration of Prozac 20–40 mg/d. All three groups were treated for 6 weeks. The therapeutic effects and adverse reaction were evaluated by Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS) respectively in the three groups. Results The effective rate was 86.7% in the acupuncture-medication group, 63.3% in Prozac Group A and 87.9% in Prozac Group B. The therapeutic effect was better in the acupuncture-medication group than in Prozac Group A, and there was no significant difference in comparisonwith Prozac Group B (P>0.05). But the occurrence rate of drug adverse reaction was higher in Prozac Group B than in the acupuncture-medication group. Conclusion Simultaneous application of acupuncture and medication is a therapeutic method with affirmative effect and less side effect for post-stroke depression.