中药内服配合灌肠治疗慢性溃疡性结肠炎临床研究

目的:观察中药内服配合灌肠治疗慢性溃疡性结肠炎(ulcerative colitis,UC)大肠湿热证的临床疗效。方法:50例随机分为两组,治疗组25例,给予中药汤剂内服并配合灌肠治疗,对照组25例口服美沙拉嗪,治疗30天后评价临床疗效、主要症状评分、肠黏膜评分及疾病活动指数评分(DAI),观察不良反应。结果:总有效率治疗组88.0%,对照组76.0%,两组比较有统计学意义(P0.05)。两组治疗后腹痛、腹泻、脓血便症状积分均明显降低(P0.05),但治疗组症状积分明显低于对照组(P0.05)。治疗后治疗组肠黏膜积分改善优于对照组(P0.05)。治疗后治疗组DAI评分改善优于对照组(P0.05)。结论:中药内服配合灌肠治疗UC大肠湿热证疗效肯定,能明显改善临床症状,且无明显不良反应。

Clinical Study on Chronic Ulcerative Colitis Treated by Orally Taking Combined Enema of Chinese Herbs

Objective：To observe the effect of Chinese herbal decoction for oral taking and enema on chronic ulcerative colitis（UC） with the large intestine damp heat syndrome in TCM.Methods：50 UC patients were randomized into treatment group of 25 cases treated by Chinese herbal decoction for oral taking and enema,and control group of 25 cases medicated by mesalaminc 1g each time,4 times a day.After the treatment for 30 days in succession,the clinical effect was evaluated with the main symptom scores and intestinal mucosa scores.And the adverse reactions were also observed.Results：The total effective rate of the treatment group was 88.0%,better than 76.0% of the control group（P0.05）.The symptom scores including abdominal pain,diarrhea,and purulent bloody stool of the patients of both groups were significantly lowered（P0.05）,and the scores of abdominal pain and diarrhea of the treatment group were significantly lower than those of the control group（P0.05）.The improvement of the intestinal mucosa score of the treatment group was better than that of the control group（P0.05）.The improvement of the DAI score of the treatment group was better than that of the control group（P0.05）.Conclusion：Chinese herbal decoction for oral taking and enema is effective for chronic UC with the large intestine damp heat syndrome in TCM,and worth of clinical promotion.