绝经后妇女活性氧与成骨细胞的关系

为探讨活性氧与成骨细胞的相关性,以进一步阐明活性氧与骨质疏松症的内在联系,选择符合纳入标准的绝经后妇女,测定其骨密度（BMD）,根据骨密度分为骨质疏松组、骨量减少组及正常组各30例。检测各组研究对象的血清丙二醛（MDA）、超氧化物歧化酶（SOD）及骨钙素（BGP）,比较各组之间的MDA、SOD及BGP的不同,并分析MDA、SOD与BGP的相关性。结果显示,MDA与BGP呈负相关（r=-0.404,P〈0.01）,SOD与BGP呈正相关（r=0.333,P〈0.01）;骨质疏松组的MDA较骨量减少组及正常组升高而SOD含量降低（P〈0.01）;骨质疏松组的BGP较骨量减少组及正常组降低（P〈0.05和P〈0.01）。表明活性氧与成骨细胞密切相关,绝经后骨质疏松患者体内的活性氧水平较正常人增高,而成骨细胞的活性降低,提示活性氧能抑制成骨细胞的活性,活性氧可能参与和促进了骨质疏松症的病理过程。

THE CORRELATION BETWEEN ACTIVE OXYGEN AND OSTEOBLAST IN POSTMENOPAUSAL WOMEN

In order to study the correlation between active oxygen and osteoblast,and probe futher the interal relation between active oxygen and osteoporosis(OS),90 cases of postmenopausal women agree with standard measured their bone mineral density(BMD)were divided averagely into 3 groups:group A(osteoporosis),group B(bone mass reduction)and group C(normal).The serum malondialdehyde(MDA),superoxide dismutase(SOD)and osteocalcin(BGP)of 3 groups were measured and compared,and the correlation of MDA,SOD and BGP analyzed.The result showed that MDA level was negatively correlated with BGP(r=-0.404,P<0.01),SOD level was postitively correlated with BGP(r=0.333,P<0.01);MDA level of group A was significantly higher than those of group B and C,and SOD level was lower by contraries(P<0.01);BGP level of group A like SOD was lower than those of group B and C(P<0.05 and P<0.01),suggesting that active oxygen was related closely to osteoblast,and the level of active oxygen in postmenopausal patients with OS higher than the normal,on the contrary,the activity of osteoblast was lower,indicating active oxygen could reduce activity of osteoblast,which may take part in and accelerate the course of OS.