| 川芎嗪对家兔再植血管内皮细胞功能的影响 |
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| 引用本文： | 梁德,韩清民,等.川芎嗪对家兔再植血管内皮细胞功能的影响[J].中医正骨,2001,13(11):3-4. |
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| 作者姓名： | 梁德 韩清民 |
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| 作者单位： | 广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院，广州中医药大学第一附属医院 510405，510405，510405，510405，510405，5104 |
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| 基金项目： | 广东省中医药管理局资助课题 (课题号 :97180 ) |
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| 摘 要： | 为探讨川芎嗪对血管内皮细胞功能的影响，将24只新西兰大白兔随机分为川芎嗪组，生理盐水组，每组各8只动物。分离股动脉，切断，显微镜下吻合血管，川芎嗪组用药量为5mg.kg^-1，肝素组用药量为60u.kg^-1，均加入0．9％生理盐水320ml，生理盐水组用等量生理盐水，各组分别于术后静脉注射给药，每天1次，连用14天，分别于术后1，3，7，14天从股静脉抽血检测ET，NO，PGI2／TXA2，结果川芎嗪组和肝素组的ET值低于生理盐水组；而川芎嗪组和肝素组的NO值则高于生理盐水组，川芎组的NO值高于肝素组，川芎嗪组和肝素组的PGI2／TXA2值高于重量盐水组，认为川芎嗪具有保护再植血管内皮细胞，防止血检形成的作用。
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| 关 键 词： | 川芎嗪 药效学 血管内皮细胞 病理生理学 内皮素 一氧化氮 血液 兔 |
EFFECT OF LIGUSTRAZINE ON THE RABBIT'S VASCULAR ENDOTHELIAL CELL AFTER ANASTOMOSIS |
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| Liang De,Han Qingmin,Jin Daxiang,et al The First Affiliated Hospital of Guangzhou TCM University.EFFECT OF LIGUSTRAZINE ON THE RABBIT'S VASCULAR ENDOTHELIAL CELL AFTER ANASTOMOSIS[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2001,13(11):3-4. |
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| Authors: | Liang De Han Qingmin Jin Daxiang The First Affiliated Hospital of Guangzhou TCM University |
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| Institution: | Liang De,Han Qingmin,Jin Daxiang,et al The First Affiliated Hospital of Guangzhou TCM University,510405 |
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| Abstract: | To study the effect of the ligudtrazine(TMP) on the function of vascular endothelial cell(VEC). Methods: Twenty-four New Zealand white big rabbits were allocated to TMP group, heparin group and Normal Saline(N.S) group. The rabbits' femoral arteries were cut off and anastomosed with microscope. The trial grug was administered by intravenous injection after operation once a day lasting 14 days. The rabbits were tested the ET,NO and PGI2/TXA2 AT 1,3,7,14 day after operation.Results: Both the TMP and heparin aoulp decrease the value of ET and increase the value of NO and PGI2/TXA2. Conclusion: The TMP could improve the function of VEC and avou/id thembsis. |
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| Keywords: | ligustrazine(TMP)/pharmcodynamics vascular endothelial cell/ pathothysiology endothelin/blood nitrous oxide/blood experimental study animal rabbit |
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