| 艾灸对急性胃黏膜损伤大鼠热休克蛋白与相关炎性细胞因子的影响 |
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| 引用本文： | 杜燕,易受乡,林亚平,洪金标,彭宏,黄芸,常小荣,吴焕淦.艾灸对急性胃黏膜损伤大鼠热休克蛋白与相关炎性细胞因子的影响[J].上海针灸杂志,2010,29(5):269-272. |
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| 作者姓名： | 杜燕 易受乡 林亚平 洪金标 彭宏 黄芸 常小荣 吴焕淦 |
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| 作者单位： | 1. 湖南中医药大学针灸推拿学院,长沙,410007
2. 上海市针灸经络研究所,上海,200030 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划，教育部博士点科基金资助项 |
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| 摘 要： | 目的探讨艾灸对急性胃黏膜损伤的保护作用及其炎症反应的抑制机制。方法健康SPF级SD大鼠,随机分对照组、模型组、艾灸组和艾灸非穴位组。采用无水乙醇灌胃制备急性胃黏膜损伤模型。艾灸足三里、中脘穴,按GUTH法计算胃黏膜损伤指数（UI）,HE染色观察胃黏膜组织形态学变化,免疫组织化学法检测胃黏膜细胞中HSP70的表达,放免法测定血清中炎性细胞因子的含量。结果与对照组比较模型组胃黏膜损伤指数、血清中炎性细胞因子含量明显升高（P〈0.01）,胃黏膜组织炎性浸润明显。与模型组相比,艾灸组胃黏膜损伤指数、血清中炎性细胞因子含量明显降低（P〈0.01或P〈0.05）,胃黏膜组织形态较为完好,HSP70大量表达（P〈0.01）。结论艾灸足三里、中脘穴对大鼠急性胃黏膜损伤具有一定的保护作用,其机制可能与诱导机体产生大量HSP70抑制炎性细胞因子的释放有关。
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| 关 键 词： | 艾灸 艾条灸 HSP70 炎性细胞因子 胃黏膜损伤 大鼠 |
Effect of Moxibustion on Heat Shock Protein and Related Inflammatory Cells in Rats with Acute Gastric Mucosal Injury |
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| DU Yan,YI Shou-xiang,LIN Ya-ping,HONG Jin-biao,PENG Hong,HUANG Yun,CHANG Xiao-rong,WU Huan-gan.Effect of Moxibustion on Heat Shock Protein and Related Inflammatory Cells in Rats with Acute Gastric Mucosal Injury[J].Shanghai Journal of Acupuncture and Moxibustion,2010,29(5):269-272. |
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| Authors: | DU Yan YI Shou-xiang LIN Ya-ping HONG Jin-biao PENG Hong HUANG Yun CHANG Xiao-rong WU Huan-gan |
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| Institution: | DU Yan1,YI Shou-xiang1,LIN Ya-ping1,HONG Jin-biao1,PENG Hong1,HUANG Yun1,CHANG Xiao-rong1,WU Huan-gan2. 1.School of Acupuncture-moxibustion , Massotherapy,Hunan University of Traditional Chinese Medicine,Changsha 410007,China,2.Research Institute of Acupuncture , Meridian,Shanghai Academy of Traditional Chinese Medicine,Shanghai 200030 |
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| Abstract: | Objective To explore the protective effect of moxibustion against acute gastric mucosal injury and the mechanism of its inhibition of inflammatory reaction. Methods Healthy SPP class SD rats were randomly allocated to control, model, moxibustion and non-acupoint moxibustion groups. A model of gastric mucosal injury was made by gavage of absolute alcohol. Moxibustion was performed on points Zusanli and Zhonhwan. Gastric mucosal injury index was calculated by the GUTH method. Histomorphologic changes in gastr... |
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| Keywords: | HSP70 |
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