针刺联合腔内理疗治疗黄素化未破裂卵泡综合征临床观察

目的观察针刺联合腔内理疗对肾虚型黄素化未破裂卵泡综合征（LUFS）促排卵及患者卵泡液中血管内皮生长因子（VEGF）水平的影响,并探讨其作用机制。方法80例LUFS患者随机分为治疗组（针刺联合腔内理疗组）和对照组（HCG组）。观察患者治疗前后生殖内分泌水平、卵泡膜血流、卵泡排出情况的变化,卵泡液中VEGF的水平及与卵泡膜血流（RI）的相关性。结果治疗组可改善内分泌水平、卵泡膜血流,与对照组比较P〈0.01;周期排卵率高于对照组P〈0.01;卵泡液中VEGF平均水平高于对照组,但无统计学意义;卵泡液中VEGF水平与卵泡膜血流RI呈负相关。结论针刺联合腔内理疗可有效治疗肾虚型黄素化未破裂卵泡综合征,其机制可能与改善患者内分泌水平,调节卵巢旁/自分泌产生VEGF,改善卵泡膜血流有关。

Clinical Observations on Combined Treatment of Luteinized Unruptured Follicle Syndrome (LUFS) with Acupuncture and Intracavitary Physiotherapy

Objective To investigate the effect of combined acupuncture and intracavitary physiotherapy on ovulation induction and follicular fluid Vascular Endothelial Growth Factor （VEGF） levels in patients with LUFS of kidney deficiency type and explore the mechanism of its action. Methods Eighty patients with LUFS were randomly allocated to a treatment （combined acupuncture and intracavitary physiotherapy） group and a control （HCG） group. Reproductive endocrine levels, follicular membrane blood flow, ovulation, and follicular fluid VEGF levels and its correlation with follicular membrane blood flow RI were examined before and after treatment. Results Endocrine levels and follicular membrane blood flow improved in the treatment group and there were significant differences compared with the control group （P〈0.01）. The periodic ovulation rate was higher in the treatment group than in the control group （P〈0.01）. Follicular fluid VEGF levels were higher in the treatment group than in the control group, but there was no statistically significant difference. Follicular fluid VEGF levels had a negative correlation with follicular membrane blood flow RI. Conclusion Combined acupuncture and intracavitary physiotherapy can effectively treat luteinized unruptured follicle syndrome of kidney deficiency type. Its mechanism may be related to improving endocrine levels, regulating ovarian paracrine/autocrine VEGF and ameliorating follicular membrane blood flow in the patients.