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元安颗粒对慢性心力衰竭大鼠心肌组织黏附分子表达的影响
引用本文:范建民,张稳,唐莹,廖若夷,雍苏南.元安颗粒对慢性心力衰竭大鼠心肌组织黏附分子表达的影响[J].中国中医急症,2013,22(4):563-565.
作者姓名:范建民  张稳  唐莹  廖若夷  雍苏南
作者单位:湖南中医药大学第一附属医院,湖南长沙,410007
基金项目:湖南中医药大学青年教师科研基金课题资助项目
摘    要:目的探讨元安颗粒对慢性心力衰竭(CHF)大鼠心肌组织黏附分子表达的影响,研究其可能的作用机制。方法采用结扎WKY大鼠冠状动脉前降支法造成心肌梗死后形成CHF大鼠模型。观察心肌细胞病理变化。用ELISA法检测血清中心肌组织黏附分子表达情况。结果给药4周后,各组治疗前后比较,元安颗粒高、中、低剂量组与卡托普利组均能够降低血清中心肌组织黏附分子表达,差异有统计学意义,其中元安颗粒高剂量组疗效显著。结论元安颗粒是治疗CHF的有效方药。

关 键 词:元安颗粒  慢性心力衰竭大鼠  心肌组织黏附分子

Effect of Yuan 'an Granule on Adhesion Molecule Expression in Myocardium of CHF Rats
Institution:FAN Jian-min,ZHANG Wen,TANG Ying,et al.(The First Hospital of Hunan University of Chinese Medicine,Hunan,Changsha,410007,China )
Abstract:Objective: To investigate the effect of Yuan'an Granule on adhesion molecule expression in CHF rats and to study the mechanism of Yuan'an Granule on CHF.Methods: Through adhesion molecule expressions detected by ELISA method,the pathological changes in myocardium were observed in CHF rats models which were established by the ligating the left anterior descending coronary artery.Results: After 4 weeks,there were some obvious differences in the descending the expressions of adhesion molecule expressions of myocardium in the captopril group and the Yuan'an Granule group.Conclusion: It is effective of Yuan'an Granule in CHF.
Keywords:Yuan'an Granule  CHF rats  Myocardium adhesion molecule
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