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大黄煎剂对急性肝衰竭大鼠肝性脑病防治机制的实验研究
引用本文:邱华,毛德文,韦艾凌.大黄煎剂对急性肝衰竭大鼠肝性脑病防治机制的实验研究[J].中国中医急症,2007,16(2):195-197.
作者姓名:邱华  毛德文  韦艾凌
作者单位:广西中医学院第一附属医院,南宁,530023
摘    要:目的观察大黄煎剂对急性肝衰竭大鼠肝性脑病的影响,并探讨其作用机制。方法用皮下注射TAA造成大鼠实验性暴发性肝衰竭。将大鼠60只随机分为空白组、模型组、大黄煎剂组和乳果糖组;造模前3日开始灌胃给药。测定各组大鼠血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、血氨(NH3)、内毒素(LPS)水平,肠内容物ph值,肝线粒体肿胀度及线粒体内单氨氧化酶(MAO)、谷胱甘肽-S-转移酶(GSH—ST)、过氧化氢酶(CAT)活力。结果大黄煎剂组血清AST、ALT、NH3、LPS水平显著降低,肠内容物pH值下降,肝线粒体对外加钙离子引发肿胀的敏感性及MAO、GSH—ST、CAT的活力增强,与模型组比较有显著差异。结论大黄煎剂对肝性脑病具有防治作用,其机制可能是通过抑制肠道内细菌的繁殖,减少肠内氨的生成;通过泻下作用,缩短NH3、LPS等毒素在体内聚集、停留的时间;降低肠道pH,抑制肠道对NH3的吸收;保护肝线粒体的结构和功能,促进NH3的代谢。

关 键 词:肝性脑病  血氨  肠源性内毒素  肝线粒体  大黄煎剂
文章编号:1004-745X(2007)02-0195-03
修稿时间:2006年7月11日

The Experimental Study on the Mechanism of Rheum Offcinale Decoction on Hepatic Ence phalopathy in Rats with Acute Hepatic Failure
QIU Hua,MAO De-wen,WEI Ai-ling.The Experimental Study on the Mechanism of Rheum Offcinale Decoction on Hepatic Ence phalopathy in Rats with Acute Hepatic Failure[J].Journal of Emergency in Traditional Chinese Medicine,2007,16(2):195-197.
Authors:QIU Hua  MAO De-wen  WEI Ai-ling
Abstract:Objective:To investigate the influence of Rheum Offcianle Decoction on the Hepatic encephalopathy in rats with actue hepatic failure, and to explore the mechanism. Methods:The acute hepatic failure rat models were induced by injection thioacetamide (TAA). 60 rats were divided into 4 groups randomly: the blank group,the modle group, the rheum officinale decoction group and the lactulose group. Administration of gastric infusion was executed 3 days before model-making. The leves of AST, ALT, NH3, LPS in serum, the PH of caecum content, the swelling and action of MAO, GSH-ST, CAT in hepatic mitochondria were detected.Results:Rheum Officinale Decoction was able to notably reduce the levels of AST, ALT, NH3, LPS in serum and the pH of caecum content; increase the sensitivity of swelling to the exotic Ca2 and the action of MAO, GSH-ST, CAT in hepatic mitochondria, compare with the modle group. Conclusions:Rheum Officinale Decoction had effect of resisting hepatic encephalopathy. the mechanism might be, reducing the production of NH3 by restrainting the reproduction of bacteria in insestines; shortening the settle time of NH3,LPS by dysentery; preventing the absorption of NH3 by lowing the PH of caecum; speeding the metabolism of NH3 by protecting hepatic mitochondria.
Keywords:Hepatic Encephalopathy  NH3  LPS  hepatic mitochondria  Rheum Officinale Decoction
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