| 清热中药对ApoE基因缺陷小鼠动脉粥样硬化斑块的影响 |
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| 引用本文： | 盛小刚,潘光明,郑朝阳,赖仁奎,吴瑜,邹旭.清热中药对ApoE基因缺陷小鼠动脉粥样硬化斑块的影响[J].中国中医急症,2011,20(2):257-258,290. |
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| 作者姓名： | 盛小刚 潘光明 郑朝阳 赖仁奎 吴瑜 邹旭 |
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| 作者单位： | 广东省中医院,广东,广州,510120 |
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| 基金项目： | 广东省自然科学基金资助项目 |
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| 摘 要： | 目的观察穿心莲、黄芩、知母、牡丹皮和青蒿对ApoE基因缺陷小鼠动脉粥样硬化斑块的影响。方法以ApoE基因缺陷小鼠制作动脉粥样硬化模型,随机分为对照组、穿心莲组、黄芩组、知母组、牡丹皮组、青蒿组及辛伐他汀组,治疗13周后测定血脂、超敏C反应蛋白（hs-CRP）,并取主动脉进行病理学观察,测量斑块面积、血管横截面积、脂质中心面积、最小纤维帽厚度,计算校正斑块面积（斑块面积/血管横截面积）及脂质中心面积占斑块面积百分比。结果与对照组比较,各清热中药组血脂无明显差异,但hs-CRP明显下降。黄芩组、知母组、青蒿组的校正斑块面积明显低于对照组,各中药组脂质中心面积明显低于对照组,穿心莲组、黄芩组、青蒿组的脂质中心面积在斑块中的百分比明显低于对照组;各中药组的最小纤维帽厚度明显高于对照组。结论上述清热中药可能干预ApoE缺陷小鼠动脉粥样硬化斑块的形态结构,稳定斑块,其作用可能与抗炎有关。
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| 关 键 词： | 动脉粥样硬化 易损斑块 清热中药 |
Effect of Clearing Heat Herbs on Atherosclerotic Plaque in Mice with Apolipoprotein E Deficient |
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| SHENG Xiao-gang,PAN Guang-ming,ZHENG Zhao-yang,et al Guangdong Provincial Hospital of TCM.Effect of Clearing Heat Herbs on Atherosclerotic Plaque in Mice with Apolipoprotein E Deficient[J].Journal of Emergency in Traditional Chinese Medicine,2011,20(2):257-258,290. |
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| Authors: | SHENG Xiao-gang PAN Guang-ming ZHENG Zhao-yang Guangdong Provincial Hospital of TCM |
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| Institution: | SHENG Xiao-gang,PAN Guang-ming,ZHENG Zhao-yang,et al Guangdong Provincial Hospital of TCM(Guangzhou,Guangdong 510120) |
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| Abstract: | Objective:To observe effects of paniculta,scutellaria,anemarrhena,cortex moutan and artemisia on atherosclerotic plaque in mice with apolipoprotein E deficient.Methods:Model mice were divided randomly into the control group,the paniculta group,the scutellaria group,the anemarrhena group,the cortex moutan group,the aremisia group and the simvastatin group.After 13 weeks treatments,the lipid level and the hs-CRP content were detected.The aorta indices were observed by the pathological method including the pla... |
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| Keywords: | Atheroselerosis Vulnerable plaque Clearing heat herb |
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