| IL-1及TNF-α在关节炎大鼠模型血清中表达的实验研究 |
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| 引用本文： | 肖金鱼,王炳胜,王书杰.IL-1及TNF-α在关节炎大鼠模型血清中表达的实验研究[J].中国中医急症,2011,20(4):607-608. |
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| 作者姓名： | 肖金鱼 王炳胜 王书杰 |
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| 作者单位： | 解放军第二五一医院,河北,张家口,075000 |
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| 摘 要： | 目的检测白细胞介素1（IL-1）、肿瘤坏死因子-α（TNF-α）在佐剂性关节炎（AA）大鼠模型血清中的水平。方法建立AA大鼠模型,根据X线片及组织病理学的特点证实造模成功。用ELISA法检测AA大鼠模型血清中炎性细胞因子IL-1、TNF-α的水平。结果与对照组大鼠比较,模型组大鼠血清中IL-1、TNF-α水平明显升高。结论模型组大鼠血清中含有大量的IL-1、TNF-α,提示IL-1、TNF-α在类风湿关节炎的发病过程中起着重要作用。
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| 关 键 词： | 类风湿关节炎 佐剂性关节炎 细胞因子 白细胞介素-1 肿瘤坏死因子-α |
Expression of IL-1 and TNF-a in Adjuvant Arthritis Rats Mottles |
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| XIA Jin-yu,WANG Bing-sheng,WANG Shu-jie.Expression of IL-1 and TNF-a in Adjuvant Arthritis Rats Mottles[J].Journal of Emergency in Traditional Chinese Medicine,2011,20(4):607-608. |
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| Authors: | XIA Jin-yu WANG Bing-sheng WANG Shu-jie |
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| Institution: | XIAO Jin-yu,WANG Bing-sheng,WANG Shu-jie No.251 Hosptal of PLA(Zhangjiakou 075000,Hebei) |
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| Abstract: | Objective：To detect the expression characteristice of IL-1 and TNF-α in adjuvant arthritis（AA） rats model.Methods：AA rats model was established,the the serum level of IL-1 and TNF-α were determined by ELISA and the degree of pathogenicity as well as the pathological characteristice were assayed by histopathological techniques and joint roentgenography.Results：Compared with the control group,the IL-1 and the TNF-α were increased obviously in the model group.Conclusion：The serum level of IL-1 and TNF-α might involve in the pathogenesis of rheumatoid arthritis. |
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| Keywords: | Rheumatoid arthritis Adjuvant arthritis Cell factor IL-1 TNF-α |
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