| 葛根素对血管性痴呆大鼠脑组织Na~+-K~+-ATP酶含量、梗死体积及病理学改变的影响 |
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| 引用本文： | 朱慧渊.葛根素对血管性痴呆大鼠脑组织Na~+-K~+-ATP酶含量、梗死体积及病理学改变的影响[J].中国中医急症,2010,19(3):483-484. |
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| 作者姓名： | 朱慧渊 |
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| 作者单位： | 陕西中医学院,咸阳,712038 |
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| 摘 要： | 目的 观察葛根素对血管性痴呆(VaD)大鼠腩组织Na+-K+-A3TP酶的含量及病理学改变的影响.方法 采用中动脉阻塞法制备VaD动物模型,检测脑组织含量,HE染色病理及梗死体积变化.结果 模型组较空白组海马及大脑皮质Na+-K+-ATP酶含量减少,神经元丢失及胶质细胞增生,大脑梗死面积明显增加.葛根素组较模型组海马及大脑皮质Na+-K+-ATP酶含量、神经元损伤得以恢复,大脑梗死体积有所改善.结论 葛根素对血管性痴呆有一定防治作用.
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| 关 键 词： | 血管性痴呆 大鼠 葛根素 Na+-K+-ATP酶 梗死体积 |
Effects of Puerarin on Na~+-K~+-ATPase Levels of Brain,Pathologic Changes and Infarct Sizes in Vascular Dementia Rats |
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| ZHU Hui-yuan.Effects of Puerarin on Na~+-K~+-ATPase Levels of Brain,Pathologic Changes and Infarct Sizes in Vascular Dementia Rats[J].Journal of Emergency in Traditional Chinese Medicine,2010,19(3):483-484. |
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| Authors: | ZHU Hui-yuan |
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| Institution: | ZHU Hui-yuan Shaanxi University of Chinese Medicine(Xianyang 712038) |
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| Abstract: | Objective:To observe the effect of puerarin on Na+-K+-ATPase levels of brain and pathologic changes in vascular dementia(VaD) rats.Methods:The VaD rat model was established by middle cerebral artery occlusion.The Na+-K+-ATPase levels of brain,pathologic changes(by HE staining) and infarct sizes were measured.Results:Compared with blank group,the Na+-K+-ATPase levels in cerebral cortex and hippocampus were reduced,the nerve cells were damaged,the glial cells proliferated and the infarct sizes were augmented,... |
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| Keywords: | Vascular dementia Rats Puerarin Na+K+-ATPase Infarct size Pathology |
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