首页 | 本学科首页   官方微博 | 高级检索  
检索        

健脾化湿法治疗腹泻型肠易激综合征的临床研究
引用本文:王思玉,彭美哲,李享,陈思,李帷,张琳,朱培一,汪红兵.健脾化湿法治疗腹泻型肠易激综合征的临床研究[J].北京中医药,2014(4):246-249.
作者姓名:王思玉  彭美哲  李享  陈思  李帷  张琳  朱培一  汪红兵
作者单位:首都医科大学附属北京中医医院,北京100010
基金项目:北京市科学技术委员会首都临床特色应用研究资助项目(Z111107058811057)
摘    要:目的观察健脾化湿法治疗腹泻型肠易激综合征(IBS-D)的疗效,探寻中医药治疗IBS—D可能的客观化评价指标。方法将60例IBS.D患者用随机数字表法分为试验组和对照组,分别采用参苓白术散加减和匹维溴铵治疗,2组均治疗4周。分别在治疗前后记录主要中医临床症状及中医证候积分,检测血清胃肠激素5-羟色胺(5-HT)、降钙素相关基因肽(CGRP)、血管活性肠肽(VIP)、胆囊收缩素(CCK)的含量。结果中医证候总体疗效比较,试验组总有效率为80.8%,对照组为65.2%,差异有统计学意义(P〈0.05)。在改善腹痛即泻、腹部隐痛、情志抑郁、神疲乏力单项症状方面试验组优于对照组(P〈0.05)。2组治疗后胃肠激素含量均较治疗前有所下降,试验组CGRP改善尤其优于对照组(P〈0.05)。结论健脾化湿法治疗IBS—D具有良好的临床疗效,能够显著改善患者血清胃肠激素水平。

关 键 词:肠易激综合征  腹泻  健脾化湿法  胃肠激素

Clinical study of spleen-strengthening and dampness-expelling method for the treatment of predominant irritable bowel syndrome
WANG Si-yu,PENG Mei-zhe,LI Xiang,CHEN Si,LI Wei,ZHANG Lin,ZHU Pei-yi,WANG Hong-bing.Clinical study of spleen-strengthening and dampness-expelling method for the treatment of predominant irritable bowel syndrome[J].Beijing Journal of Traditional Chinese Medicine,2014(4):246-249.
Authors:WANG Si-yu  PENG Mei-zhe  LI Xiang  CHEN Si  LI Wei  ZHANG Lin  ZHU Pei-yi  WANG Hong-bing
Institution:( Beijing Hospital of TCM, Affiliated to Capital Medical University, Beijing 100010, China)
Abstract:Objective To observe the efficacy of spleen-strengthening and dampness-expelling method for the treatment of predominant irritable bowel syndrome( IBS-D), so as to explore the possible objective outcome measures of TCM for IBS-D. Methods By random digital table sixty cases of IBS-D were divided into a treatment group and a control, in which powder of modified Shenling Baizhu and Pinaverium Bromide were applied respectively. The treatment in both groups lasted for 4 weeks. The main TCM clinical symptom sand TCM syndrome scores were recorded and gastrointestinal hormones, including 5-hydroxytyptamine(5-HT), calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) were tested before and after treatment. Results As for total efficacy of TCM syndrome, the total effective rate was 80. 8% in the treatment group and 65.2% in the control group, which had statistical differences ( P 〈 0. 05 ). The treatment was superior to the control group in improving clinical symptoms such as abdominal pain-induced diarrhea, abdominal dull pain, depression and fatigue ( P 〈 0. 05 ). After treatment gastrointestinal hormones were decreased in both groups; the improvement of CGRP in the treatment group was superior to that in the control group(P 〈 0. 05). Conduslon The spleen-strengthening and dampness-expelling method has superior clinical efficacy in the treatment of IBS-D, which could significantly improve the level of gastrointestinal hormone.
Keywords:predominant irritable bowel syndrome  diarrhea  spleen-strengthening and dampness-expelling method  gastrointestinal hormone
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号