无花果果实中化学成分研究

目的研究桑科榕属植物无花果Ficus carica果实的化学成分。方法综合运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱以及制备型高效液相色谱等技术进行系统分离,根据化合物的理化性质及波谱数据鉴定化合物的化学结构。结果从无花果果实的90%乙醇提取物中分离得到了16个化合物,分别鉴定为怀特酮(1)、甘草宁G(2)、4′-羟基-5,7-二甲氧基-6-(3-甲基-丁烯基)-异黄酮(3)、猫尾草异黄酮(4)、indicanine C(5)、木豆素(6)、美迪紫檀素(7)、高丽槐素(8)、4-羟基-3-甲氧基-8,9-亚甲二氧基紫檀烷(9)、3-羟基-9,10-二甲氧基紫檀烷(10)、松脂素(11)、杜仲树脂酚(12)、丁香树脂醇(13)、8-羟基松脂醇(14)、3-羟基-1-(4-羟基-3-甲氧基苯)-1-丙酮(15)和4-羟基-3-甲氧基苯乙醇(16)。结论所有化合物均为首次从无花果中分离得到。

Chemical constituents from fruits of Ficus carica

Objective To study the chemical constituents from the fruits of Ficus carica. Methods The chemical constituents of F. carica were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatographies, and preparative HPLC. Their structures were identified by physicochemical properties, spectroscopic analysis, as well as comparisons with the data reported in literature. Results A total of 16 compounds were isolated from the 90% ethanol extract of the fruits of F. carica, which were identified as wighteone (1), gancaonin G (2), 4''-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (3), alpinumisoflavone (4), indicanine C (5), cajanin (6), medicarpin (7), maackiain (8), 4-hydroxy-3-methoxy-8,9-methylenedioxy pterocarpan (9), 3-hydroxy-8,9-dimethoxypterocarpan (10), pinoresinol (11), medioresinol (12), syringaresinol (13), 8-hydroxy pinoresinol (14), 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-1-propanone (15), and 4-hydroxy-3-methoxyphenthyl alcohol (16).Conclusion All compounds are isolated from F. carica for the first time.