| 霸王鞭内生真菌烟曲霉中1个新的生物碱类化合物 |
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| 引用本文： | 陈彦君,祝丽君,于红梅,侯雨婷,陈毅坚,杜刚,周敏,叶艳青,董淼.霸王鞭内生真菌烟曲霉中1个新的生物碱类化合物[J].中草药,2019,50(22):5400-5403. |
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| 作者姓名： | 陈彦君 祝丽君 于红梅 侯雨婷 陈毅坚 杜刚 周敏 叶艳青 董淼 |
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| 作者单位： | 云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500,云南民族大学化学与环境学院, 云南民族大学民族药资源化学国家民委教育部重点实验室, 云南 昆明 650500 |
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| 基金项目： | 国家自然科学基金资助项目（31560099）；国家自然科学基金资助项目（31860099）；云南省高校科技创新团队支持计划 |
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| 摘 要： | 目的研究霸王鞭Euphorbia royleana内生真菌烟曲霉Aspergillus fumigatus的次生代谢产物。方法运用多种色谱方法对菌株发酵液醋酸乙酯萃取部分进行分离纯化,采用波谱分析方法对化合物的结构进行鉴定。结果从烟曲霉次生代谢产物中分离得到3个化合物,分别鉴定为(R)-2-丙基己基-2H-1,2,3-三唑-4-羧酸酯(1)、decumbenone A(2)和圆弧菌醇(3)。结论化合物1为新化合物,命名为烟曲霉三唑酯A。
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| 关 键 词： | 霸王鞭 烟曲霉 内生真菌 次生代谢产物 (R)-2-丙基己基-2H-1, 2, 3-三唑-4-羧酸酯 烟曲霉三唑酯A 圆弧菌醇 |
| 收稿时间： | 2019/6/28 0:00:00 |
A new alkaloid from endophytic fungus Aspergillus fumigatus of Euphorbia royleana |
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| CHEN Yan-jun,ZHU Li-jun,YU Hong-mei,HOU Yu-ting,CHEN Yi-jian,DU Gang,ZHOU Min,YE Yan-qing and DONG Miao.A new alkaloid from endophytic fungus Aspergillus fumigatus of Euphorbia royleana[J].Chinese Traditional and Herbal Drugs,2019,50(22):5400-5403. |
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| Authors: | CHEN Yan-jun ZHU Li-jun YU Hong-mei HOU Yu-ting CHEN Yi-jian DU Gang ZHOU Min YE Yan-qing and DONG Miao |
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| Institution: | Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China,Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China and Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China |
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| Abstract: | Objective To study the secondary metabolites of endophytic fungus Aspergillus fumigatus from Euphorbia royleana. Methods The fermentation liquor of the fungal strain A. fumigatus was isolated and purified using various chromatographic methods. The structures of the compounds were identified by spectroscopic analysis. Results Three compounds were isolated and their structures were identified as (R)-2-propylhexyl-2H-1,2,3-triazole-4-carboxylate (1), decumbenone A (2), and (+)-cyclopenol (3). Conclusion Compound 1 is a new compound isolated from this fungus, which is identified as aspergillus triazolate A. |
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| Keywords: | Euphorbia royleana Boiss Aspergillus fumigatus endophytic fungus secondary metabolites (R)-2-propylhexyl-2H-1, 2, 3-triazole-4-carboxylate aspergillus triazolate A (+)-cyclopenol |
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