| 大叶山楝萜类化学成分及其生物活性研究进展 |
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| 引用本文： | 陈彦伍,董发武,秦天丽,孙恒,宋俏,何红平.大叶山楝萜类化学成分及其生物活性研究进展[J].中草药,2019,50(22):5621-5631. |
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| 作者姓名： | 陈彦伍 董发武 秦天丽 孙恒 宋俏 何红平 |
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| 作者单位： | 云南中医药大学中药学院, 云南 昆明 650500,云南中医药大学中药学院, 云南 昆明 650500,云南中医药大学中药学院, 云南 昆明 650500,云南中医药大学中药学院, 云南 昆明 650500,云南中医药大学中药学院, 云南 昆明 650500,云南中医药大学中药学院, 云南 昆明 650500;云南中医药大学民族医药学院, 云南 昆明 650500 |
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| 基金项目： | 国家自然科学基金资助项目（31760100）；云南省科技计划中医联合面上项目[2015FB 205（-022）] |
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| 摘 要： | 大叶山楝Aphanamixis grandifolia为楝科山楝属植物,具有舒筋活络、通痹及祛风除湿等功效。大叶山楝中含有柠檬苦素类衍生物、甘遂烷型三萜、达玛烷型三萜、环阿尔廷烷型三萜、二萜及倍半萜等萜类化合物,具有杀虫、抗肿瘤、抗炎、抗疟疾和抑菌等生物活性。对大叶山楝萜类化学成分及其生物活性研究进展进行综述,以期为该植物的研究和开发利用提供参考。
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| 关 键 词： | 大叶山楝 萜类 柠檬苦素类 杀虫活性 抗肿瘤活性 抑菌活性 |
| 收稿时间： | 2019/3/19 0:00:00 |
Research progress on chemical constituents and biological activities of Aphanamixis grandifolia |
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| CHEN Yan-wu,DONG Fa-wu,QIN Tian-li,SUN Heng,SONG Qiao and HE Hong-ping.Research progress on chemical constituents and biological activities of Aphanamixis grandifolia[J].Chinese Traditional and Herbal Drugs,2019,50(22):5621-5631. |
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| Authors: | CHEN Yan-wu DONG Fa-wu QIN Tian-li SUN Heng SONG Qiao and HE Hong-ping |
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| Institution: | College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China,College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China,College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China,College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China,College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China and College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China;College of Chinese National Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China |
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| Abstract: | Aphanamixis grandifolia, a perennial herb of genus Aphanamixis (Meliaceae), has the effect of relaxing sinew and activating collaterals, dredging arthralgia, expelling wind-evil and removing wetness, etc. Previous phytochemical investigations on this plant resulted in the isolation of various terpenoid derivatives, including limonoids, tirucallane-type, dammarane-type, and cycloartane-type triterpenoids, as well as diterpenoids and sesquiterpenoids. Moreover, bioactivities of those compounds were evaluated, which displayed extensive biological properties, such as antibacterial, insecticidal, antineoplastic, anti-inflammatory, antimalarial, and antibacterial activities, etc. In this paper, the systematic classification, chemical constituents, and biological activities of A. grandifolia were summarized. It may provide the reference for the further studies of this plant. |
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| Keywords: | Aphanamixis grandifolia Bl terpenoids limonoids insecticidal activities antineoplastic activities antibacterial activities |
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