三七普通细粉与超微粉中三七皂苷R1、人参皂苷Rb1及人参皂苷Rg1体外溶出行为的比较研究

目的 研究三七普通细粉与超微粉中三七皂苷R₁、人参皂苷Rb₁及人参皂苷Rg₁的溶出行为，探讨粉体粒径对皂苷类成分溶出的影响。方法 采用桨法和HPLC技术同时分析不同粒径三七粉中三七皂苷R₁、人参皂苷Rb₁、人参皂苷Rg₁的体外溶出情况，比较不同粒径粉末的溶出速率。结果 超微粉碎后3种皂苷类成分的溶出速率均显著提高。结论 超微粉碎有助于三七饮片中皂苷类成分的溶出，粉碎粒度对有效成分的溶出有显著的影响。

Comparison on in vitro dissolution behavior of notoginsenoside R1, ginsenosides Rb1 and Rg1 between ordinary fine and ultrafine powder of Panax notoginseng

Objective To compare the dissolution behavior of notoginsenoside R₁, ginsenoside Rb₁ and Rg₁ between the ordinary fine and ultrafine powder of Panax notoginseng and to investigate the effect of micronization on the dissolution of saponin ingredients in P. notoginseng. Methods The oar method was adopted. The in vitro dissolution of the three kinds of saponins including notoginsenoside R₁, ginsenoside Rg₁ and Rb₁ in different particle sizes was determined by HPLC. The dissolving rates of the powder in various particle sizes were compared. Results The dissolving rates of the three kinds of saponins were greatly increased after ultramicro-pulverization. Conclusion The ultramicro-pulverization is helpful to the dissolution of saponins in P. notoginseng pieces, and the particle size of the powder exerts the great influence on the dissolution of the three kinds of saponins.