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荷叶大豆及其合剂调脂活性部位的研究
引用本文:杜力军,孙虹,李敏,金文,徐丽珍.荷叶大豆及其合剂调脂活性部位的研究[J].中草药,2000,31(7):526-528.
作者姓名:杜力军  孙虹  李敏  金文  徐丽珍
作者单位:中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094
摘    要:目的:通过体内外实验探讨荷叶大豆调脂的活性部位及其作用特点,方法:以急性高脂血症小鼠为整体模型观察药物对血清胆固醇及甘油三酯的影响,体外给药观察药物对肝细胞合成胆固醇的影响。结果:荷叶大豆的水提取部分及其生物碱和黄酮均有调脂作用,大豆黄酮对体外肝细胞合成胆固醇有抑制的趋势。结论:荷叶和大豆均有调脂作用,其主要活性部位在黄酮和生物碱,其作用特点在于促进胆固醇的代谢方面。

关 键 词:荷叶  大豆  调血脂  中药合剂  高脂血症  小鼠

Studies on the Active Components in the Leaf of Nelumbo nucifera and Black Soybean and Their Mixture with Blood Lipid Regulating Effect
Du Lijun,Sun Hong,Li Min,Jin Wen and Xu Lizhen.Studies on the Active Components in the Leaf of Nelumbo nucifera and Black Soybean and Their Mixture with Blood Lipid Regulating Effect[J].Chinese Traditional and Herbal Drugs,2000,31(7):526-528.
Authors:Du Lijun  Sun Hong  Li Min  Jin Wen and Xu Lizhen
Institution:Institute of Medicinal Plant Developments, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094;Institute of Medicinal Plant Developments, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094;Institute of Medicinal Plant Developments, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094;Institute of Medicinal Plant Developments, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094;Institute of Medicinal Plant Developments, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094
Abstract:To study the effect of the leaf of Nelumbo necifera Gaertn. and black soybean (Glycine soja Sieb. et Zucc.) on blood lipid level, in order to identify the active Components of the two herbs by experiments in vivo and in vitro. By determining the change of serum, cholesterol (TC) and triglyceride (TG) of acute hyperlipemic mouse model after drug administration. By culturing liver cells with the test drugs to assess the effect on TC synthesis. The aqueous extracts of both test drugs and their alkaloid and flavonoid contents could lower serum TC and TG levels of hyperlipemic mice and inhibit the synthesis of TC by liver cells in vitro. Both lotus leaf and soybean could lower blood lipid levels due to their water solublc active Component of flavonoids and alkaloids.
Keywords:the leaf of Nelumbo necifera Gaertn    black soybean  blood lipid
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