骨疏灵颗粒防潮辅料优选

目的 评价辅料对骨疏灵吸湿性的影响，优选骨疏灵颗粒剂防潮辅料。方法 通过吸湿率考察优选辅料的种类及配比；从乙醇浓度、吸湿率、成型性、休止角、颗粒外观等方面优选成型工艺。结果 骨疏灵颗粒的最佳防潮混合辅料为乳糖-甘露醇（4：1），药辅比1：2；85%乙醇制粒，颗粒大小均匀，成型性较好，临界相对湿度76%。结论 为骨疏灵颗粒的开发研制提供了实验依据。

Optimization of damp-proof excipients for Gushuling Granules

Objective To evaluate the effect of the excipients on hygroscopicity of Gushuling Granules and optimize the damp-proof excipients. Methods Moisture absorption rate was used to optimize the type and ratio of materials; The concentration of ethanol, moisture absorption rate, formability, angle of repose, and appearance of Gushuling Granules were used to optimize the molding technology. Results The best damp-proofing excipients were as follows: the hybrid materials were lactose-mannitol 4:1, medicine-auxiliary ratio of 1:2, and with 85% ethanol to granulate. Gushuling Granules were good uniform, damp-proofing, and formability, the critical relative humidity was 76%. Conclusion The preparation technology is stable. The study provides the experimental evidences for the research and development of Gushuling Granules.