德钦乌头中的二萜生物碱

目的 研究乌头属植物德钦乌头Aconitum ouvrardianum根的二萜生物碱类化学成分.方法 采用反复硅胶柱色谱进行分离纯化,根据谱学数据和对照TLC分析鉴定化合物的结构.结果 从德钦乌头根的醋酸乙酯提取物中分离得到12个化合物,分别鉴定为塔拉乌头胺(1)、彭乌碱乙(2)、卡马考宁(3)、黄草乌碱亭(4)、粗茎乌头碱甲(5)、贡乌生(6)、14-乙酰黄草乌碱亭(7)、展花乌头碱(8)、黄乌宁(9)、膝乌亭丁(10)、异塔拉乌头定(11)、翠雀它灵(12).结论 12个化合物均为C-3位或C-6位无含氧取代的C19-二萜生物碱,且均为首次从该植物中分离得到.乌头碱型C19-二萜生物碱为德钦乌头药材的主要药用化学成分.

Diterpene alkaloids from roots of Aconitum ouvrardianum

Objective To study the diterpene alkaloids from the roots of Aconitum ouvrardianum. Methods The silica gel column was used for the isolation and purification of the compounds from the roots of A. ouvrardianum. Their structures were identified on the bases of spectral data, such as NMR, TLC, and references. Results Twelve diterpene alkaloids: talatizamine (1), pengshenine B (2), cammaconine (3), sachaconitine (4), crassicauline (5), liljestrandisine (6), 14-acetylsachaconitine (7), chasmaconitine (8), vilmorinine (9), geniculatine D (10), isotalatizidine (11), and detaline (12) were isolated and identified in the acetic ether extract from the roots of A. ouvrardianum. Conclusion All these compounds are C₁₉-diterpene alkaloids without C-3 or C-6 oxygen substitution and are found in this plant for the first time. The C₁₉-diterpene alkaloids are the main chemical constituents in A. ouvrardianum.