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| 复方丹参片对阿尔茨海默病大鼠脑内氨基酸类神经递质含量的影响 | |
| 引用本文： | 覃仁安,罗佳波,陈矛,黄竹英,王虹,杨东升,陈松光.复方丹参片对阿尔茨海默病大鼠脑内氨基酸类神经递质含量的影响[J].中草药,2004,35(8):905-907. |
| 作者姓名： | 覃仁安 罗佳波 陈矛 黄竹英 王虹 杨东升 陈松光 |
| 作者单位： | 1. 第一军医大学,博士后科研流动站、广州医药集团博士后科研工作站、广州白云山中药厂研发中心,广东,广州,510515 2. 第一军医大学,中医系,广东,广州,510515 3. 广州白云山中药厂,广东,广州,510515 |
| 基金项目： | 广州市企业博士后基金资助项目 ( 2 0 0 2 0 2 ) |
| 摘 要： | 目的 研究复方丹参片对实验性阿尔茨海默病(AD)大鼠．脑内氨基酸类神经递质含量的影响，揭示其防治AD的作用机制。方法 采用HPLC方法检测：实验性AD大鼠脑内天冬氨酸(Asp)、谷氨酸(Glu)、甘氨酸(Gly)和7一氨基丁酸(GABA)等氨基酸类神经递质的含量。结果 复方丹参片能明显降低实验性AD大鼠脑内兴奋性氨基酸Glu的含量，升高抑制性氨基酸Gy和GABA的含量。结论 复方丹参片降低兴奋性氨基酸含量，以对抗兴奋性氨基酸的毒性，这可能是其防治AD的机制之一。 |
| 关 键 词： | 复方丹参片 阿尔茨海默病 氨基酸类神经递质 高效液相色谱 |
| 文章编号： | 0253-2670(2004)08-0905-03 |
| 收稿时间： | 2003/11/13 0:00:00 |
| 修稿时间： | 2003年11月13 |
Effect of Compound Danshen Tablets on amino acid neurotransmitters in brain of Alzheimer's disease rats |
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| QIN Ren-an,LUO Jia-bo,CHEN Mao,HUANG Zhu-ying,WANG Hong,YANG Dong-sheng and CHEN Song-guang.Effect of Compound Danshen Tablets on amino acid neurotransmitters in brain of Alzheimer''s disease rats[J].Chinese Traditional and Herbal Drugs,2004,35(8):905-907. | |
| Authors: | QIN Ren-an LUO Jia-bo CHEN Mao HUANG Zhu-ying WANG Hong YANG Dong-sheng and CHEN Song-guang |
| Institution: | QIN Ren-an1,LUO Jia-bo2,CHEN Mao3,HUANG Zhu-ying3,WANG Hong3,YANG Dong-sheng3,CHEN Song-guang3 |
| Abstract: | Object To study the effect of Compound Danshen Ta blets (CDST) on the contents of amino acid neurotransmitters in brain of experimental Alzheimer's disease (AD) rats to reveal the mechanism of CDST in the prevention and treatment to AD. Methods Contents of amino acid neurotransmitters Asp, Glu, Gly, GABA in AD rat brain were determined by HPLC. Results CDST significantly decreased the excitatory Glu content, and increased the inhibitory Gly and GABA contents. Conclusion CDST could lower the toxicity of excitatory amino acid by decreasing its contents, which may be one of the mechanisms of CDST in prevention and treatment to AD. |
| Keywords: | Compound Danshen Tablets (CDST) Alzheimer's disease amino acid neurotransmitters HPLC |
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