| 基于外翻肠囊模型的黄芪-附子配伍对附子6种生物碱肠吸收的影响研究 |
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| 引用本文： | 孔小强,蒋且英,罗云,梁新丽,黄国勇,季苗苗,廖正根,黄香梅.基于外翻肠囊模型的黄芪-附子配伍对附子6种生物碱肠吸收的影响研究[J].中草药,2017,48(23):4928-4934. |
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| 作者姓名： | 孔小强 蒋且英 罗云 梁新丽 黄国勇 季苗苗 廖正根 黄香梅 |
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| 作者单位： | 江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西中医药大学 实验动物科技中心, 江西 南昌 330004,江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004,江西省新余市中医院, 江西 新余 338000 |
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| 基金项目： | 国家自然科学基金资助项目（81660757）；江西省卫生计生委中医药科研课题（2016A021） |
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| 摘 要： | 目的研究黄芪-附子药对配伍对附子3种单酯型生物碱(苯甲酰次乌头原碱、苯甲酰新乌头原碱、苯甲酰乌头原碱)和3种双酯型生物碱(次乌头碱、新乌头碱、乌头碱)肠吸收的影响。方法运用大鼠外翻肠囊模型,选择十二指肠、空肠、回肠为研究肠段,以表观渗透系数(P_(app))为评价指标,考察黄芪对附子6种生物碱P_(app)的影响。结果当附子-黄芪3∶1时,黄芪在十二指肠和回肠能显著降低双酯型生物碱的P_(app),在3种肠段均能降低单酯型生物碱的P_(app);当附子-黄芪1∶1时,除次乌头碱在回肠外,黄芪能显著降低双酯型生物碱的P_(app);当附子-黄芪1∶3时,黄芪能显著降低单酯型生物碱(除回肠外)的P_(app),在各肠段均能显著降低3种双酯型生物碱的P_(app)。结论黄芪可抑制附子生物碱的吸收,且其抑制作用因配伍比例、生物碱的种类和肠段不同而不同。
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| 关 键 词： | 黄芪 附子 外翻肠囊模型 肠吸收 配伍 苯甲酰次乌头原碱 苯甲酰新乌头原碱 苯甲酰乌头原碱 次乌头碱 新乌头碱 乌头碱 |
| 收稿时间： | 2017/5/12 0:00:00 |
Effect of Radix Astragali and Aconiti Lateralis Radix Preparata on intestinal absorption of six kinds of alkaloids in Aconiti Lateralis Radix Preparata |
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| KONG Xiao-qiang,JIANG Qie-ying,LUO Yun,LIANG Xin-li,HUANG Guo-yong,JI Miao-miao,LIAO Zheng-gen and HUANG Xiang-mei.Effect of Radix Astragali and Aconiti Lateralis Radix Preparata on intestinal absorption of six kinds of alkaloids in Aconiti Lateralis Radix Preparata[J].Chinese Traditional and Herbal Drugs,2017,48(23):4928-4934. |
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| Authors: | KONG Xiao-qiang JIANG Qie-ying LUO Yun LIANG Xin-li HUANG Guo-yong JI Miao-miao LIAO Zheng-gen and HUANG Xiang-mei |
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| Institution: | Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Experimental Animal Science and Technology Center, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Key Laboratory of Modern Preparation of Chinese Meteria Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China and Xinyu Municipal Hospital of Jiangxi Province, Xinyu 338000, China |
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| Abstract: | Objective To study the effect of Radix Astragali and Aconiti Lateralis Radix Preparata on the intestinal absorption of the three kinds of monoester-type alkaloids (benzoylthioate, benzoyl neostearine, and benzoyl aconitine) and three kinds of diester-type alkaloids (hypaconitine, neaconitine, and aconitine) in Aconiti Lateralis Radix Preparata. Methods The rat duodenum, the jejunum, and the ileum were selected to study the intestinal segment. The apparent permeability coefficient (Papp) was used to evaluate the effect of Radix Astragali on the Papp of six kinds of alkaloids in Aconiti Lateralis Radix Preparata. Results When Aconiti Lateralis Radix Preparata and Radix Astragali was 3:1, Radix Astragali can significantly reduce the dipeptide alkaloid Papp in the duodenum and ileum and reduce the monoester-type alkaloid Papp in three kinds of intestinal segments; When Aconiti Lateralis Radix Preparata and Radix Astragali was 1:1, except in the ileum, Radix Astragali can significantly reduce the Papp of the diester-type alkaloid; When Aconiti Lateralis Radix Preparata and Radix Astragali was 1:3, Radix Astragali can significantly reduce the Papp of the monoester-type alkaloid (except the parenteral) and significantly reduced the Papp of the three diester-type alkaloids. Conclusion Radix Astragali can inhibit the absorption of aconite alkaloids, and its inhibition effect is different due to different compatibility ratios, types of alkaloids and intestinal segments. |
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| Keywords: | Radix Astragali Aconiti Lateralis Radix Preparata valgus capsule model intestinal absorption compatibility benzoylthioate benzoyl neostearine benzoyl aconitine hypaconitine mesaconine aconitine |
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