| 冰片及石菖蒲促进羟基红花黄色素A透过血脑屏障的实验研究 |
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| 引用本文： | 吴雪,欧阳丽娜,向大位,向大雄.冰片及石菖蒲促进羟基红花黄色素A透过血脑屏障的实验研究[J].中草药,2011,42(4):734-737. |
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| 作者姓名： | 吴雪 欧阳丽娜 向大位 向大雄 |
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| 作者单位： | 1. 中南大学湘雅二医院,湖南省中药制剂新技术重点研究室,湖南,长沙,410011;北京积水潭医院,北京,100035;中南大学药学院,湖南,长沙,410013
2. 中南大学湘雅二医院,湖南省中药制剂新技术重点研究室,湖南,长沙,410011;中南大学药学院,湖南,长沙,410013 |
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| 摘 要： | 目的考察芳香开窍药冰片及石菖蒲对羟基红花黄色素A(HSYA)血脑屏障(BBB)通透性的影响。方法 ig给予大鼠20.00 mg/kg HSYA混悬液,分别配伍冰片及石菖蒲水提液,给药后采集大鼠血浆及脑组织。HPLC测定大鼠血浆及脑组织内HSYA浓度,以各组HSYA的AUC脑/AUC血为评价指标,进行冰片及石菖蒲对BBB通透性影响的评价。结果 HSYA、HYSA+冰片、HYSA+石菖蒲组HSYA在大鼠血浆及脑匀浆中的AUC0～8 h分别为(77 228.76±2 873.19)、(81 949.04±2 283.11)、(28 479.63±2 431.71)ng.mL-1.min及(55 925.0±2 434.28)、(82 768.53±3 277.00)、(70 914.29±2 900.71)ng.mL-1.min,各组AUC脑/AUC血分别为0.72、1.01、2.49。结论 HSYA配伍冰片及石菖蒲后,AUC脑/AUC血均显著升高(P<0.05)。冰片及石菖蒲均对BBB有开启作用,且石菖蒲可影响HSYA在大鼠体内的分布。
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| 关 键 词： | 冰片 石菖蒲 羟基红花黄色素A 血脑屏障 芳香开窍药 |
| 收稿时间： | 2010/7/14 0:00:00 |
Enhancing effect of Borneolum Syntheticum and Acori Talarinowii Rhizoma on penetrating blood-brain barrier of hydroxysafflor yellow A |
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| WU Xue,OUYANG Li-n,XIANG Da-wei and XIANG Da-xiong.Enhancing effect of Borneolum Syntheticum and Acori Talarinowii Rhizoma on penetrating blood-brain barrier of hydroxysafflor yellow A[J].Chinese Traditional and Herbal Drugs,2011,42(4):734-737. |
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| Authors: | WU Xue OUYANG Li-n XIANG Da-wei and XIANG Da-xiong |
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| Institution: | WU Xue1,2,3,OUYANG Li-na1,XIANG Da-wei1,XIANG Da-xiong1,3 1.Key Laboratory of Traditional Chinese Medicine Preparation,Hunan Province,Second Xiangya Hospital of Central South University,Changsha 410011,China 2.Beijing JiShuiTan Hospital,Beijing 100035,China 3.School of Pharmceutical Sciences,Central South University,Changsha 410013,China |
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| Abstract: | Objective To investigate the enhancing effect of Borneolum Syntheticum and Acori Talarinowii Rhizoma on penetrating blood-brain barrier (BBB) of hydroxysafflor yellow A (HSYA) in rat. Methods The concentration of HSYA in rat plasma and brain was determinated after ig administration of 20.00 mg/kg of HSYA to rats with or without Borneolum Syntheticum and Acori Talarinowii Rhizoma. And then, the character of penetrating BBB through the result of the AUCbrain/AUCblood was evaluated. Results The AUC0-8h were (77 228.76±2 873.19), (81 949.04±2 283.11), and (28 479.63±2 431.71) ng.mL-1.min for blood and (55 925.0±2 434.28), (82 768.53±3 277.00), and (70 914.29±2 900.71) ng.mL-1.min for brain of the control group, Borneolum Syntheticum group, and Acori Talarinowii Rhizoma group. The AUCbbrain/AUCblood were 0.72, 1.01, and 2.49, respectively. Conclusion Borneolum Syntheticum and Acori Talarinowii Rhizoma do enhance the penetrating BBB of HSYA (P<0.05). Further more, Acori Talarinowii Rhizoma could affect the distribution of HSYA in rats. |
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| Keywords: | Borneolum Syntheticum Acori Talarinowii Rhizoma hydroxysafflor yellow A(HSYA) blood-brain barrier(BBB) drug of resuscitstion with aromatics |
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