| 伸筋草注射液的制备及其对大鼠实验性矽肺的疗效 |
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| 引用本文： | 贺立中,黄泽华,王惠茹.伸筋草注射液的制备及其对大鼠实验性矽肺的疗效[J].中草药,1996,27(5):286-289. |
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| 作者姓名： | 贺立中 黄泽华 王惠茹 |
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| 作者单位： | 铁道部第二工程局职业病防治院!成都610101铁道部第二工程局中心医院药剂科(贺立中)，铁道部第二工程局职业病防治院!成都610101(黄泽华，王惠茹) |
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| 基金项目： | 铁道部“八五”重点卫生科研课题 |
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| 摘 要： | 将伸筋草提取液分别用超滤法和水醇法制成注射液，分组对染尘大鼠腹腔注射给药5周，解剖后测定各组大鼠肺的鲜重、干重、胶原含量和病理分级等指标，结果表明．用超滤法制备的注射液预防性治疗给药对大鼠实验性矽肺有较好疗效，而用水醇法制备的注射液疗效不佳。还对伸筋草的抗矽有效成分进行了探讨。
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| 关 键 词： | 伸筋草注射液 矽肺 超滤 |
| 收稿时间： | 1995/2/14 0:00:00 |
Shenjincao Injection Preparation and Curative Effect in Experimental Silicosis of Rats |
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| He Lizhong,Huang Zehua and Wang Huiru.Shenjincao Injection Preparation and Curative Effect in Experimental Silicosis of Rats[J].Chinese Traditional and Herbal Drugs,1996,27(5):286-289. |
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| Authors: | He Lizhong Huang Zehua and Wang Huiru |
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| Institution: | Occupational Diseases Prevention and Treatment Centre,the Second Enginering;Occupational Diseases Prevention and Treatment Centre,the Second Enginering;Occupational Diseases Prevention and Treatment Centre,the Second Enginering |
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| Abstract: | Shenjincao injection was prepared from the extract of Lycopodium cernuum L. by ultrafiltration or wateralcohol methods,respectively,and then injected intra-peritoneally in groups of rats contaminated with quartz powder to assess their prophylactic effects. After 5 weeks of treatment,the rats were dissected and the fresh and dried weights,collagen content and the pathologic grading of the lungs were examined. Results showed that Shenjincao injection prepared with ultrafiltration was effective for the prophylactic treatment of experimental silicnsis of rats,while that prepared with water-alcohol method was devoid of such effect. The antisilicosis active principle of Shenjincao was explored and discussed. |
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