西红花及其活性成分对肝脏疾病作用及其机制的研究进展

西红花Crocus sativus是一种具有多种生理功能的传统药食两用物质,已有大量研究报道其可以预防和治疗精神类疾病、神经退行性疾病、心血管疾病以及高脂血症等疾病。研究结果表明,西红花主要通过其抗炎、抗氧化、抗凋亡和调节脂质代谢等药理作用对各种肝脏疾病产生治疗效果。对西红花及其活性成分治疗肝脏疾病的药理作用及其作用机制进行综述,为西红花在临床上发挥更广泛的治疗作用及其抗肝脏疾病作用的深入研究提供科学合理的参考。

Research progress on effect and mechanism of Crocus sativus and its active components against liver diseases

Crocus sativus is a traditional medicinal and edible substance with multiple physiological functions. A large number of studies have demonstrated that C. sativus can prevent and treat mental diseases, neurodegenerative diseases, cardiovascular diseases, and hyperlipidemia. Results show that C. sativus can protect against liver diseases mainly through its anti-inflammatory, anti-oxidant, anti-apoptosis and lipid metabolism regulation effects. The pharmacological effects and mechanism of C. sativus and its active components in treatment of liver diseases are reviewed in this paper, in order to provide a scientific support for further research and a wider clinical use of C. sativus in treatment of liver diseases.