通关藤的化学成分

目的 研究了通关藤Marsdenia tenacissima的化学成分.方法 利用正、反相硅胶柱色谱分离提纯,经理化常数测定,结合MS、1R、UV、~1H-NMR、~(13)C-NMR等现代波谱学技术确定了其结构.结果 从通关藤水提取物中分离得到10个化合物,分别鉴定为美国商陆脑苷(poke-weed cerebroside,I)、β-D-黄夹吡喃糖苷-(1→4)-β-D-磁麻吡喃糖甲苷(Ⅱ)、11α、12β-丙酮缩二羟基通关藤苷元B(Ⅲ)、牛奶菜醇A(IV)、1-(4-羟基-3-甲氧基-苯基)-2-{2-甲氧基-4--1-(E)-丙烯-3-醇]-苯氧基}-丙烷-1,3-二醇(赤式)(V)、半乳糖醇(VI)、东莨菪素(Ⅶ)、直立牛奶菜双糖(marsectobiose,Ⅷ)、胡萝卜苷(Ⅸ)、丁二酸(X).结论 化合物I、V是首次从该属植物中分离得到;化合物Ⅱ、Ⅵ～Ⅷ、X为首次从该植物中分离得到.

Chemical constituents of Marsdenia tenacissima

Objective To study the chemical constituents in the stems of Marsdenia tenacissima. Methods Ten compounds were isolated and purified by silica gel column chromatography and Sephadex LH-20. The chemical structures of the compounds were elucidated by their physicochemical properties and spectral data, such as MS, IR, UV, ~1H-NMR, and ~(13)C-NMR. Results The compounds were obtained from the water extract of the plant. They were poke-weed cerebroside ( I ), methyl β-D-theveropyranosyl-(l→4)-β-D-cymaropyranoside (Ⅱ), 11α, 12β-acetonide-tenacigenin B (Ⅲ), conduritol A (Ⅳ), l-(4-hy-droxy-3-methoxyphenyl)-2-{ 2-methoxy-4-l-(E)-propen-3-ol]-phenoxy}-propan-l, 3-diol ( V ), D-galacti-tol (Ⅵ), scopoletin (Ⅶ), marsectobiose (Ⅷ), daucosterol (Ⅸ), and amber acid (X). Conclusion Compounds I and V are isolated from the plants of Marsdenia R. Br. for the first time; Compounds Ⅱ, Ⅵ-Ⅶ, and X are isolated from the title plant for the first time.