| 杭白菊、当归、丹参提取液抑制黄褐斑形成及机制研究 |
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| 引用本文： | 应军,倪庆纯,杨威,黄远铿,郭健敏,肖百全,张志妮.杭白菊、当归、丹参提取液抑制黄褐斑形成及机制研究[J].中草药,2011,42(5):958-962. |
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| 作者姓名： | 应军 倪庆纯 杨威 黄远铿 郭健敏 肖百全 张志妮 |
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| 作者单位： | 广州医药工业研究院,国家广州新药安全评价研究重点实验室,广东,广州,510240 |
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| 基金项目： | 粤港关键领域重点突破项目 |
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| 摘 要： | 目的观察杭白菊、当归、丹参提取液对im黄体酮及紫外(UV)照射导致的黄褐斑小鼠模型的抗氧化与抗黄褐斑形成作用。方法将小鼠随机分成对照组、模型组、维生素C组、杭白菊组、当归组、丹参组共6组。采用im黄体酮及辅助UV照射方法建立黄褐斑小鼠模型。测定各组肝脏及皮肤组织中的谷胱甘肽过氧化酶(GSH-Px)、超氧化物歧化酶(SOD)、酪氨酸酶(TYR)活性与总抗氧化能力(T-AOC),以及丙二醛(MDA)、一氧化氮(NO)、肝脏脂褐质水平,并测定血液流变学指标,进行皮肤病理学检查。结果杭白菊、当归、丹参提取液显著增强黄褐斑小鼠肝脏和皮肤中GSH-Px、SOD活性,降低MDA水平,抑制TYR增加,使黑素细胞(MC)生成减少,抑制黑色素合成,从而减轻皮肤色素沉着。结论杭白菊、当归、丹参提取液有一定的防治黄褐斑的功效,其作用与提高机体抗氧化能力,抑制TYR活性,减少黑色素的合成以及改善机体的血液流变学有关。
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| 关 键 词： | 杭白菊 当归 丹参 黄褐斑 抗氧化 酪氨酸酶 黑色素 |
| 收稿时间： | 2010/12/6 0:00:00 |
Inhibition of extracts from Hangzhou Chrysanthemum Flos, Angelicae Sinensis Radix, and Salviae Miltiorrhizae Radix et Rhizoma on formation of chloasma and their mechanism |
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| YING Jun,NI Qing-chun,YANG Wei,HUANG Yuan-keng,GUO Jian-min,XIAO Bai-quan and ZHANG Zhi-ni.Inhibition of extracts from Hangzhou Chrysanthemum Flos, Angelicae Sinensis Radix, and Salviae Miltiorrhizae Radix et Rhizoma on formation of chloasma and their mechanism[J].Chinese Traditional and Herbal Drugs,2011,42(5):958-962. |
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| Authors: | YING Jun NI Qing-chun YANG Wei HUANG Yuan-keng GUO Jian-min XIAO Bai-quan and ZHANG Zhi-ni |
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| Institution: | YING Jun,NI Qing-chun,YANG Wei,HUANG Yuan-keng,GUO Jian-min,XIAO Bai-quan,ZHANG Zhi-ni State Key Laboratory of New Drug Evaluation in Guangzhou,Guangzhou Institute of Pharmaceutical Industry,Guangzhou 510240,China |
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| Abstract: | Objective To investigate the oxidation resistance and removing chloasma function of the extract from Hangzhou Chrysanthemum Flos,Angelicae Sinensis Radix,and Salviae Mmiltiorrhizae Radix et Rhizoma in cholasma model induced by progesterone and ultraviolet radiation.Methods The cholasma model was establised with progesterone(20 mg/kg) by im injection or ultraviolet radiation in female mice.The effects of each group on GSH-Px,SOD,tyrosinase(TYR),MDA,NO,T-AOC,and lipofuscin in skin and liver were detected,and ... |
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| Keywords: | Hangzhou Chrysanthemum Flos Angelicae Sinensis Radix Salviae Miltiorrhizae Radix et Rhizoma chloasma anti-oxidation tyrosinase melanin |
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