| 头孢拉定对黄芩苷大鼠体内药动学的影响 |
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| 引用本文： | 车庆明,陈颖,彭金年.头孢拉定对黄芩苷大鼠体内药动学的影响[J].中草药,2006,37(10):1530-1532. |
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| 作者姓名： | 车庆明 陈颖 彭金年 |
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| 作者单位： | 北京大学药学院,北京,100083 |
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| 基金项目： | 国家自然科学基金资助项目(30171139) |
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| 摘 要： | 目的研究头孢拉定对黄芩苷在大鼠体内药动学的影响。方法用HPLC-ECD方法测定头孢拉定和黄芩苷合并给药组与黄芩苷单独给药组黄芩苷在大鼠体内的血药浓度,比较两者的药动学参数。结果头孢拉定和黄芩苷合并给药组黄芩苷Cmax为(782.63±469.37)ng/mL,AUC0~24h为(8407.86±3476.14)ng/mL·h;黄芩苷单独给药组黄芩苷Cmax为(2645.62±601.42)ng/mL,AUC0~24h为(28952.90±5731.42)ng/mL·h。结论两者药动学参数存在显著性差异(P<0.05),口服头孢拉定严重降低了黄芩苷的血药浓度。提示临床应合理用药。
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| 关 键 词： | 黄芩苷 头孢拉定 药动学 药物相互作用 |
| 文章编号： | 0253-2670（2006）10-1530-03 |
| 收稿时间： | 2006-02-09 |
| 修稿时间： | 2006-02-09 |
Effect of Cefradine on pharmacokinetics of baicalin in rats in vivo |
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| CHE Qing-ming,CHEN Ying and PENG Jin-nian.Effect of Cefradine on pharmacokinetics of baicalin in rats in vivo[J].Chinese Traditional and Herbal Drugs,2006,37(10):1530-1532. |
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| Authors: | CHE Qing-ming CHEN Ying and PENG Jin-nian |
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| Institution: | School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;School of Pharmaceutical Sciences, Peking University, Beijing 100083, China |
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| Abstract: | Objective To study the effect of oral Cefradine on pharmacokinetics of baicalin in rats in vivo. Methods The rats were divided into two groups: one was supplied with baicalin individually and the other was supplied with the combination of Cefradine and baicalin. Plasma concentrations of two groups were detected by HPLC with electrochemical detection (ECD). The pharmacokinetic parameters were calculated by statistical analysis and compared. Results The pharmacokinetic parameters of combination administration group were C_ max (782.63±469.37) ng/mL, AUC_ 0-24 h (8 407.86±3 476.14) ng/mL·h; while the individual administration group of baicalin was C_ max (2 645.62±601.42) ng/mL, AUC_ 0-24 h (28 952.90 ±5 731.42) ng/mL·h. Conclusion The main pharmacokinetic parameters show significant difference between the two groups (P0.05). Taking Cefradine orally influences the plasma concentration of baicalin within an ideal range. |
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| Keywords: | baicalin Cefradine pharmacokinetics drug interaction |
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